关键词: 脑梗死; 高龄; 尤瑞克林; 疗效

Abstract:

【Abstract】 Objective To observe the effect of urinarykallikrein in elderly patients with acute ischemic stroke. Methods Two hundred and one elderly patients(age≥75) with acute ischemic stroke were admitted to our hospital from July 2008 to November 2010. They were enrolled in the randomized single-blind control trail. These patients were assigned to urinarykallikrein treatment group(n=100) and control group(n=101). They were both treated by identical basis therapy. The patients in the treatment group were treated by intravenous infusion administration of 0.15 PNA U urinarykallikrein diluted in 100ml 0.9% saline, once daily for 14 consecutive days. On the pre-therapy and 14st post-treatment day, the two groups were compared with the National Institutes of Health Stroke Scale(NIHSS) score and total clinical efficiency. Results After 14d treatment, NIHSS of both urinarykallikrein and control group were decreased as compared with the pretreatment (urinarykallikrein, 4.55±2.89 vs 2.54±1.96, t=7.261, P=0.002; control, 4.11±2.56 vs 3.49±2.55, t=7.439, P=0.013). The decrease of NIHSS in urinarykallikrein group was more significant than that in control group(t=2.093, P=0.023), the rate of total clinical efficiency in treatment group is greater than that in the control group(84% vs 55%, U=2896, P=0.001). Conclusion Urinarykallikrein is effective for the treatment of elderly patients with acute ischemic stroke, so it is worthy to be recommended for clinical application for elderly patients.

Key words: Acute ischemic stroke; Elderly patients; Urinarykallikrein; Efficacy