参考文献1 Goldstein AL, Slater FD, White A. Preparation, assay, and partial purification of a thymic lymphocytopoietic factor(thymosin)[J]. Proc Natl Acad Sci USA, 1966, 56:1010-1017.2 Koutrafouri V, Leondiadis L, Ferderigos N, et al. Synthesis and angiogenetic activity in the chick chorioallantoic membrane model of thymosin beta-15[J]. Peptides, 2003, 24:107-115.3 Lee SH, Son MJ, Oh SH, et al. Thymosin beta10 inhibits angiogenesis and tumor growth by interfering with Ras function[J]. Cancer Res, 2005, 65:137-148.4 Dedova IV, Nikolaeva OP, Safer D, et al. Thymosin beta4 induces a conformational change in actin monomers[J]. Biophys J, 2006, 90:985-992.5 Choe J, Sun W, Yoon SY, et al. Effect of thymosin beta15 on the branching of developing neurons[J]. Biochem Biophys Res Commun, 2005, 331:43-49.6 Vartiainen N, Pyykonen I, Hokfelt T, et al. Induction of thymosin beta(4) mRNA following focal brain ischemia[J]. Neuroreport, 1996, 7:1613-1616.7 Kim Y, Kim EH, Hong S, et al. Expression of thymosin beta in the rat brain following transient global ischemia[J]. Brain Res, 2006, 1085:177-182.8 Sapp E, Kegel KB, Aronin N, et al. Early and progressive accumulation of reactive microglia in the Huntington disease brain[J]. J Neuropathol Exp Neurol, 2001, 60:161-172.9 Rensink AA, Otte-Holler I, Ten DHJ, et al. Differential gene expression in human brain pericytes induced by amyloid-beta protein[J]. Neuropathol Appl Neurobiol, 2004, 30:279-291.10 Yang H, Cui GB, Jiao XY, et al. Thymosin-beta4 attenuates ethanol-induced neurotoxicity in cultured cerebral cortical astrocytes by inhibiting apoptosis[J]. Cell Mol Neurobiol, 2010, 30:149-160.11 Xiong Y, Zhang Y, Mahmood A, et al. Neuroprotective and neurorestorative effects of thymosin beta4 treatment initiated 6 hours after traumatic brain injury in rats[J]. J Neurosurg, 2012, 116:1081-1092.12 Morris DC, Chopp M, Zhang L, et al. Thymosin beta4 improves functional neurological outcome in a rat model of embolic stroke[J]. Neuroscience, 2010, 169:674-682.13 Smart N, Risebro CA, Melville AA, et al. Thymosin beta-4 is essential for coronary vessel development and promotes neovascularization via adult epicardium[J]. Ann NY Acad Sci, 2007, 1112:171-188.14 Banerjee I, Zhang J, Moore-Morris T, et al. Thymosin beta 4 is dispensable for murine cardiac development and function[J]. Circ Res, 2012, 110:456-464.15 乔海兵, 聂李亚, 马素永, 等. 重组胸腺素β4对大鼠心肌梗死心微血管及血管内皮生长因子表达的影响[J]. 解剖学杂志, 2010, 33:591-594.16 吕淑敏. 胸腺肽β4与体内血管再生的关系及促血管生成中的Notch通路机制的研究[D]. 浙江:浙江大学医学部, 2011.17 于虎, 马瑞珏, 张朔杨, 等. 胸腺素β4调节血管内皮生长因子、层粘连蛋白5表达, 促进糖尿病大鼠皮肤损伤愈合[J]. 中国糖尿病杂志, 2011, 19:60-63.18 Qiu P, Kurpakus-Wheater M, Sosne G. Matrix metalloproteinase activity is necessary for thymosin beta 4 promotion of epithelial cell migration[J]. J Cell Physiol, 2007, 212:165-173.19 Tang MC, Chan LC, Yeh YC, et al. Thymosin beta 4 induces colon cancer cell migration and clinical metastasis via enhancing ILK/IQGAP1/Rac1 signal transduction pathway [J]. Cancer Lett, 2011, 308:162-171.20 Cierniewski CS, Papiewska-Pajak I, Malinowski M, et al. Thymosin beta4 regulates migration of colon cancer cells by a pathway involving interaction with Ku80[J]. Ann NY Acad Sci, 2010, 1194:60-71.21 Xie D, Jauch A, Miller CW, et al. Discovery of over-expressed genes and genetic alterations in breast cancer cells using a combination of suppression subtractive hybridization, multiplex FIS-H and comparative genomic hybridization[J]. Int J Oncol, 2002, 21:499-507.22 Cha HJ, Jeong MJ, Kleinman HK. Role of thymosin beta4 in tumor metastasis and angiogenesis[J]. J Natl Cancer Inst, 2003, 95:1674-1680.23 王新波, 熊斌, 周瑞, 等. 胸腺素β4真核表达载体的构建及其对血管内皮细胞增殖的影响[J]. 武汉大学学报(医学版), 2006, 27:564-568.24 Dettin M, Ghezzo F, Conconi MT, et al. In vitro and in vivo pro-angiogenic effects of thymosin-beta4-derived peptides[J]. Cell Immunol, 2011, 271:299-307.25 Smart N, Risebro CA, Melville AAD, et al. Thymosin beta 4 induces adult epicardial progenitor mobilization and neovascularization[J]. Nature, 2007, 445:177-182.26 Selmi A, Malinowski M, Brutkowski W, et al. Thymosin β4 promotes the migration of endothelial cells without intracellular Ca2+ elevation[J]. Exp Cell Res, 2012, 318:1659 -1666.27 Hinkel R, Bock-Marquette I, Hatzopoulos AK, et al. Thymosin beta4:a key factor for protective effects of eEPCs in acute and chronic ischemia[J]. Ann NY Acad Sci, 2010, 1194:105-111.28 乔海兵, 丁大有, 聂李亚, 等. 胸腺素β4对急性心肌梗死大鼠心肌磷酸化蛋白激酶表达及纤维化的影响[J]. 解剖学杂志, 2011, 34:609-611.29 赵炎波. 胸腺素β4对循环内皮祖细胞的作用及机制[D]. 浙江:浙江大学医学部, 2011.30 Li J, Yu L, Zhao Y, et al. Thymosin β4 reduces senescence of endothelial progenitor cells via the PI3K/Akt/eNOS signal transduction pathway[J]. Mol Med Rep, 2013, 7:598-602.31 Sosne G, Qiu P, Christopherson PL, et al. Thymosin beta 4 suppression of corneal NF kappaB:a potential anti-inflammatory pathway[J]. Exp Eye Res, 2007, 84:663-669.32 Santra M, Chopp M, Zhang ZG, et al. Thymosin beta 4 mediates oligodendrocyte differentiation by upregulating p38 MAPK[J]. Glia, 2012, 60:1826-1838. |