中国卒中杂志 ›› 2013, Vol. 8 ›› Issue (12): 993-997.

• 综述 • 上一篇    下一篇

肿瘤坏死因子基因多态性与脑血管病的关系研究进展

陶曼丽1,梁志刚1,李伟2,于国平1   

  1. 1264000 烟台
    青岛大学医学院附属烟
    台毓璜顶医院神经内科
    2首都医科大学附属北京
    天坛医院神经内科
  • 收稿日期:2013-01-19 出版日期:2013-12-20 发布日期:2013-12-20
  • 通讯作者: 梁志刚 zgliang@hotmail.com

Progress in Research on the Tumor Necrosis Factor Gene Polymorphism and
Cerebrovascular Disease

  1. *Department of Neurlogy, Yantai Yuhuangding Hospital Affiliated to Qingdao University
    Medical College, Yantai 264000, China
  • Received:2013-01-19 Online:2013-12-20 Published:2013-12-20

摘要:

脑血管病的发生受环境和遗传等多方面因素影响,与炎性反应密切相关。肿瘤坏死因子 (tumor necrosis factor,TNF)作为一种促炎性因子,其基因多态性与脑血管病的关系受到人们的关注。 TNF不同基因型作为基因背景有可能决定了不同人群对疾病不同的易感性。TNF基因多态性在脑血管 发病中所起的作用,可能与其基因突变有关,但也可能存在多个位点相互协同或与其他炎症细胞因子 共同作用。本文对近年来有关TNF基因多态性与脑血管的关系研究进展进行综述,以便对脑血管病进 行风险预测、诊断及个体化治疗等方面的研究提供线索。

文章导读: 综合国内外研究,对肿瘤坏死因子的生物活性、基因多态性及其与脑血管病的关系进行综述。

关键词: 肿瘤坏死因子; 脑血管病; 基因多态性

Abstract:

Stroke is associated with inflammation. With the onset getting younger and younger in recent years, to find and identify predisposing factors of stroke, thus becomes a hot spot for targeted prevention. The occurrence of stroke is affected by many other environmental and genetic factors. And it is closely related to the inflammatory response. As tumor necrosis factor (TNF) is a pro-inflammatory factor, its gene polymorphism and the relationship between the incidences of cerebrovascular disease cause attentions. We review progress in research on the recent TNF gene polymorphism on the relationship with cerebrovascular disease in order to provide important clues in predicting cerebrovascular disease risk, diagnosing and making individualized treatment.

Key words: Tumor necrosis factor; Cerebrovascular disease; Gene polymorphism