脑缺血后运动疗法的神经再生与血管再生机制

摘要/Abstract

摘要：

缺血性卒中后的病理生理反应很复杂，单纯注重挽救神经元在临床研究中并不能有效达到神经保护作用。神经血管单位中的“血管龛”假说强调神经再生和血管再生之间复杂的相互作用，从而有效修复脑缺血损伤。本综述中主要简述了运动锻炼对缺血性卒中的保护和治疗作用，运动疗法的保护机制包括增加脑灌注、促进神经再生、侧支循环、血管再生等。本综述旨在认识血管再生的重要性，可望其成为缺血性卒中治疗的新途径。

文章导读： 运动疗法多采用影像学和行为学手段从功能角度进行机制分析，很少深入到细胞分子水平。本文从“神经血管单位”的角度，综述运动对脑缺血后神经再生和血管再生的影响及二者的相互作用。

关键词: 血管再生; 神经再生; 运动; 缺血性卒中; 神经血管单位

Abstract:

Pathophysiologic responses in brain after stroke are highly complex. Thus far, a singular focus on saving neurons alone has not revealed any clinically effective neuroprotection. To address this limitation, the concept of a neurovascular unit was developed. The vascular niche hypothesis highlights the complex interactions of neuro- and angiogenesis for regenerative and repair mechanisms in the human brain. In this review, we briefly describe the protective and therapeutic effects of exercise on stroke. The protective mechanisms induced by exercise include increased perfusion as well as mechanisms of neurogenesis, collateral recruitment and angiogenesis. The purpose of this review is to evaluate the evidence that angiogenesis is a target for recovery after an ischemic stroke.

Key words: Angiogenesis; Neurogenesis; Exercise; Ischemic stroke; Neurovascular uni

翟志永，冯娟. 脑缺血后运动疗法的神经再生与血管再生机制[J]. 中国卒中杂志, 2015, 10(01): 88-91.

ZHAI Zhi-Yong, FENG Juan. . Effects of Exercise on Brain Neurogenesis and Angiogenesis after Ischemic Stroke [J]. Chinese Journal of Stroke, 2015, 10(01): 88-91.

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