骨髓间充质干细胞治疗脑梗死的研究进展

摘要/Abstract

摘要：

骨髓间充质干细胞（bone marrow mesenchymal stem cells，BMSCs）是一类具有多项分化潜能的干细胞，通过诱导BMSCs可分化为各胚层细胞。已有动物实验证明，BMSCs治疗能够促进脑梗死后受损神经组织结构和功能的恢复，其可能的机制有：刺激神经发生和突触的形成，分泌多种神经营养因子和细胞因子，发挥免疫调节作用改变缺血区微环境，促进新生血管的形成等。对BMSCs进行修饰处理后，其治疗脑梗死效果更好，临床试验结果较乐观。

文章导读： 本文介绍了骨髓间充质干细胞移植治疗脑梗死的动物研究的效果、机制、干预等进展，并介绍了其临床研究的探索。

关键词: 骨髓间充质干细胞; 脑梗死; 移植

Abstract:

Bone marrow mesenchymal stem cells (BMSCs) is a kind of stem cells that have multiple differentiation potential. Through induced, BMSCs can differentiate into each layer cells. Animal experiments proved that BMSCs treatment can promote the recovery of damaged nerve tissue structure and function, and its possible mechanisms are stimulating neurogenesis and the formation of synapses, secreting various neurotrophic factors and cytokines for nerve protection, through the immune adjustment function to change microenvironment of ischemia area, promoting the formation of new blood vessels. Through the modification of BMSCs for treatment, the effect is better, clinical trials have optimistic results.

Key words: Bone marrow mesenchymal stem cells; Cerebral infarction; Transplant

刘新华1，曹亦宾2. 骨髓间充质干细胞治疗脑梗死的研究进展[J]. 中国卒中杂志, 2015, 10(03): 261-266.

LIU Xin-Hua*, CAO Yi-Bin. Research Progress of Bone Marrow Mesenchymal Stem Cell in the Treatment of Cerebral Infarction[J]. Chinese Journal of Stroke, 2015, 10(03): 261-266.

参考文献

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