关键词: 皮层下脑梗死; 脑白质变性; 认知评估

Abstract: Objective To investigate the association between white matter changes of subcortical infarction vascular cognitive impairment and cognitive assess scores. Methods Ninety-one patients with subcortical infarction were consecutively recruited. According to Montreal cognitive assessment(MOCA), they were divided into two groups as subcortical vascular cognitive impairment group (SVCI, 49 cases) and subcortical infarction without cognitive impairment group (SI, 42 cases). The correlation between Cognitive impairment and white matter lesions by analysis the clinical, cognitive impairment and neuroimaging characteristics of patients were explored. Results The incidence of diabetes in SVCI patients is higher than SI patients (38.78% vs 16.67%, P =0.02). Cerebral white matter changes were found in 37 cases (75.51%) of SVCI patients. There is a negative correlation between the degree of white matter lesion and visuospatial executive( Rs = - 0.415, P =0.028), memory( Rs = - 0.577, P =0.001), attention( Rs = - 0.382, P =0.001), delay recall( Rs = - 0.389, P =0.041) according to MOCA assessment ( Rs = - 0.495, P =0.002). Conclusion Diabetes is an important risk factor in SVCI patients. White matter change is the most important imaging features, and reflects the degree of cognitive impairment.

Key words: subcortical infarction; white matter change; cognitive assessment