关键词: 急性; 缺血性卒中； 抑郁-执行功能障碍综合征； 白质病变； 胆碱能通路

Abstract:

Objective To investigate the relationship between the depression-executive dysfunction syndrome(DES) after acute ischemic stroke and white matter lesions within cholinergic pathways cholinergic pathway using the cholinergic pathways hyperintensities scale(CHIPS) to rate the white matter lesions within cholinergic pathways. Methods One hundred and nineteen patients with acute ischemic stroke were recruited, which were divided into depression-executive dysfunction syndrome group and non-depressed-executive dysfunction syndrome group. All of them had a brain magnetic resonance imaging(MRI) scan, and white matter lesion on brain MRI was evaluated with the CHIPS. Results The total CHIPS scores in DES group increased significantly compared with non-DES group ( P =0.033), and the CHIPS scores in white matter lesion of high external capsule horizon in DES group increased significantly compared with non-DES group ( P =0.017). Conclusion DES after acute ischemic stroke had a strong relationship with white matter lesion within cholinergic pathways, and white matter lesion within cholinergic pathways may lead to DES.

Key words: Acute ischemic stroke; Depression-executive dysfunction syndrome; White matter lesion; Cholinergic pathway