中国卒中杂志 ›› 2015, Vol. 10 ›› Issue (12): 1020-1025.

• 专题综述 • 上一篇    下一篇

脑大动脉病变与脑白质高信号的相关性研究进展

翟菲菲,朱以诚   

  1. 100730 北京协和医院神经科
  • 收稿日期:2015-07-18 出版日期:2015-12-20 发布日期:2015-12-20
  • 通讯作者: 朱以诚 zhuych910@163.com

Cerebral Large-artery Disease Correlates of White Matter Hyperintensities

  • Received:2015-07-18 Online:2015-12-20 Published:2015-12-20

摘要:

脑大、小血管共同构成了脑的血管树,它们在结构和功能上有一定的相关性。近年来,脑 大血管病变与脑小血管病之间相关关系的研究逐渐受到重视。大动脉粥样硬化、动脉延长扩张及管 壁僵硬度增大从不同侧面反映了大血管病变的特点,脑白质高信号是脑小血管病重要的影像学表现。 本文对动脉粥样硬化、动脉延长扩张及僵硬度增大与脑白质高信号之间的相关性进行综述,以探讨 脑大血管病变与脑小血管病的关系。

文章导读: 通过回顾大动脉粥样硬化、动脉延长扩张及动脉壁僵硬度增大与WMH的相关性研究,发现大、小血管共同受到血流动力学和危险因素影响,它们之间存在相互作用,颅内动脉延长扩张、主动脉僵硬度增大与WMH相关。

关键词: 脑动脉狭窄; 脑小血管病; 脑白质高信号

Abstract:

The cerebral vascular tree is composed of cerebral large vessels and cerebral small vessels, which are structurally and functionally connected. Recently, more and more studies concern about the relationship of large-artery disease and cerebral small vessel disease (CSVD). Atherosclerosis, dolichoectasia and stiffness represent different pathophysiological and structural change of large artery. Cerebral white matter hyperintensities (WMH) is a surrogate marker of CSVD. This article reviews the association of large artery atherosclerosis, dolichoectasia and stiffness with WMH to demonstrate the relationship of large-artery disease and CSVD.

Key words: Cerebral artery stenosis; Cerebral small vessel disease; Cerebral white matter
hyperintensities