1 Liu L，Wang D，Wong KS，et al. Stroke and stroke

care in China：huge burden，significant workload，

and a national priority[J]. Stroke，2011，42：3651-

3654.

2 Bennett JS. Structure and function of the platelet

integrin alpha IIb beta3[J]. J Clin Invest，2005，115：

3363-3369.

3 中华医学会心血管病学分会，中华心血管病杂志编辑

委员会. 抗血小板治疗中国专家共识[J]. 中华心血管

病杂志，2013，41：183-194.

4 Nu rde n AT，Caen JP. An abnormal platelet

glycoprotein pattern in three cases of Glanzmann's

thrombasthenia[J]. Br J Haematol，1974，28：253-260.

5 Kumar S，Rajshekher G，Prabhakar S. Platelet

glycoprotein Ⅱb/Ⅲa inhibitors in acute ischemic

stroke[J]. Neurol India，2008，56：399-404.

6 Coller BS. Anti-GPⅡb/Ⅲa drugs：current strategies

and future directions[J]. Thromb Haemost，2001，86：

427-443.

7 Casserly IP，Topol EJ. Glycoprotein Ⅱb/Ⅲa

antagonists--from bench to practice[J]. Cell Mol Life

Sci，2002，59：478-500.

8 Pancioli AM，Brott TG. Therapeutic potential of

platelet glycoprotein Ⅱb/Ⅲa receptor antagonists

in acute ischaemic stroke：scientific rationale and

available evidence[J]. CNS Drugs，2004，18：981-988.

9 Béguin S，Kumar R，Keular ts I，et al. Fibr independent

platelet procoagulant activity requires

GPIb receptors and von Willebrand factor[J]. Blood，

1999，93：564-570.

10 Me r l i n i PA，Ros s i M，Men o z z i A，e t a l .

Thrombocytopenia caused by abciximab or tirofiban

and its association with clinical outcome in patients

undergoing coronary stenting[J]. Circulation，2004，

109：2203-2206.

11 Llevadot J，Coulter SA，Giugliano RP. A practical

approach to the diagnosis and management of

thrombocytopenia associated with glycoprotein Ⅱb/Ⅲa

receptor inhibitors[J]. J Thromb Thrombolysis，2000，9：

175-180.

12 Tcheng JE，Harrington RA，Kottke-Marchant K，et

al. Multicenter，randomized，double-blind，placebocontrolled

trial of the platelet integrin glycoprotein

Ⅱb/Ⅲa blocker integrelin in elective coronary

intervention. IMPACT Investigators[J]. Circulation，

1995，91：2151-2157.

13 Goa KL，Noble S. Eptifibatide：a review of its use

in patients with acute coronary syndromes and/or

undergoing percutaneous coronary intervention[J].

Drugs，1999，57：439-462.

14 Torgano G，Zecca B，Monzani V，et al. Effect of

intravenous tirofiban and aspirin in reducing shortterm

and long-term neurologic deficit in patients with

ischemic stroke：a double-blind randomized trial[J].

Cerebrovasc Dis，2010，29：275-281.

15 Alexander KP，Chen AY，Newby LK，et al. Sex

differences in major bleeding with glycoprotein

Ⅱb/Ⅲa inhibitors：results f rom the CRUSADE

(Can Rapid risk stratification of Unstable angina

patients Suppress ADverse outcomes with Early

implementat ion of the ACC/AHA guidelines)

initiative[J]. Circulation，2006，114：1380-1387.

16 Gurm HS，Smith DE，Collins JS，et al. The relative

safety and efficacy of abciximab and eptifibatide in

patients undergoing primary percutaneous coronary

intervention：insights from a large regional registry of

contemporary percutaneous coronary intervention[J].

J Am Coll Cardiol，2008，51：529-535.

17 Roffi M，Moliterno DJ，Meier B，et al. Impact of

different platelet glycoprotein Ⅱb/Ⅲa receptor

inhibitors among diabetic patients undergoing

percutaneous coronary intervention：Do Tirofiban

and ReoPro Give Similar Efficacy Outcomes Trial

(TARGET) 1-year follow-up[J]. Circulation，2002，

105：2730-2736.

18 A comparison of aspirin plus tirofiban with aspirin

plus heparin for unstable angina. Platelet ReceptorInhibition in Ischemic Syndrome Management

(PRISM) Study Investigators[J]. N Engl J Med，1998，

338：1498-1505.

19 Kastrati A，Mehilli J，Neumann FJ，et al. Abciximab

in patients with acute coronary syndromes undergoing

percutaneous coronary intervention after clopidogrel

pretreatment：the ISAR-REACT 2 randomized trial[J].

JAMA，2006，295：1531-1538.

20 Van't Hof AW，Ten Berg J，Heestermans T，et al.

Prehospital initiation of tirofiban in patients with STelevation

myocardial infarction undergoing primary

angioplasty (On-TIME 2)：a multicentre，double-blind，

randomised controlled trial[J]. Lancet，2008，372：537-

546.

21 Wang TY，White JA，Tricoci P，et al. Upstream

clopidogrel use and the efficacy and safety of early

eptifibatide treatment in patients with acute coronary

syndrome：an analysis from the Early Glycoprotein

Ⅱb/Ⅲa Inhibition in Patients with Non-ST-Segment

Elevation Acute Coronary Syndrome (EARLY ACS)

trial[J]. Circulation，2011，123：722-730.

22 P r id e YB，Mohanave lu S，Zork u n C，e t a l .

Association between angiographic complications and

clinical outcomes among patients with acute coronary

syndrome undergoing percutaneous coronary

intervention：an EARLYACS (Early Glycoprotein

Ⅱb/Ⅲa Inhibition in Non-ST-Segment Elevation

Acute Coronary Syndrome) angiographic substudy[J].

JACC Cardiovasc Interv，2012，5：927-935.

23 Abciximab Emergent St roke Treatment Tr ial

(AbESTT) Investigators. Emergency administration

of abciximab for treatment of patients with acute

ischemic stroke：results of a randomized phase 2

trial[J]. Stroke，2005，36：880-890.

24 Adams HP Jr，Effron MB，Torner J，et al. Emergency

administration of abciximab for treatment of patients

with acute ischemic stroke：results of an international

phase Ⅲ trial：Abciximab in Emergency Treatment of

Stroke Trial (AbESTT-Ⅱ)[J]. Stroke，2008，39：87-99.

25 Stead LG，Vaidyanathan L. Evidence-based

emergency medicine/systematic review abstract. Role

of abciximab in the management of acute ischemic

stroke[J]. Ann Emerg Med，2009，53：392-394.

26 Siebler M，Hennerici MG，Schneider D，et al. Safety

of Tirofiban in acute Ischemic Stroke：the SaTIS

trial[J]. Stroke，2011，42：2388-2392.

27 Ciccone A，Motto C，Abraha I，et al. Glycoprotein

Ⅱb-Ⅲa inhibitors for acute ischaemic stroke[J].

Cochrane Database Syst Rev，2014，3：CD005208.

28 Skagervik I，Wikholm G，Rosengren L，et al. Brain

CT perfusion in stroke in progression[J]. Eur Neurol，2008，59：98-100.

29 Philipps J，Thomalla G，Glahn J，et al. Treatment of

progressive stroke with tirofiban--experience in 35

patients[J]. Cerebrovasc Dis，2009，28：435-438.

30 Mar tin-Schild S，Shaltoni H，Abraham AT，et

al. Safety of eptifibatide for subcortical stroke

progression[J]. Cerebrovasc Dis，2009，28：595-600.

31 Rha JH，Saver JL. The impact of recanalization on

ischemic stroke outcome：a meta-analysis[J]. Stroke，

2007，38：967-973.

32 Alexandrov AV，Grotta JC. Arterial reocclusion

in stroke patients treated with intravenous tissue

plasminogen activator[J]. Neurology，2002，59：862-

867.

33 Mendonca N，Rodriguez-Luna D，Rubiera M，et

al. Predictors of tissue-type plasminogen activator

nonresponders according to location of vessel

occlusion[J]. Stroke，2012，43：417-421.

34 Zinkstok SM，Roos YB，ARTIS investigators. Early

administration of aspirin in patients treated with

alteplase for acute ischaemic stroke：a randomised

controlled trial[J]. Lancet，2012，380：731-737.

35 Straub S，Junghans U，Jovanovic V，et al. Systemic

thrombolysis with recombinant tissue plasminogen

activator and tirofiban in acute middle cerebral artery

occlusion[J]. Stroke，2004，35：705-709.

36 Seitz RJ，Sukiennik J，Siebler M. Outcome after

systemic thrombolysis is predicted by age and stroke

severity：an open label experience with recombinant

tissue plasminogen activator and tirofiban[J]. Neurol

Int，2012，4：e9.

37 Pancioli AM，Broder ick J，Brott T，et al. The

combined approach to lysis utilizing eptifibatide and

rt-PA in acute ischemic stroke：the CLEAR stroke

trial[J]. Stroke，2008，39：3268-3276.

38 Pancioli AM，Adeoye O，Schmit PA，et al. Combined

approach to lysis utilizing eptifibatide and recombinant

tissue plasminogen activator in acute ischemic strokeenhanced

regimen stroke trial[J]. Stroke，2013，44：

2381-2387.

39 Adeoye O，Knight WA，Khoury J，et al. A matched

comparison of eptifibatide plus rt-PA versus rt-

PA alone in acute ischemic stroke[J]. J Stroke

Cerebrovasc Dis，2014，23：e313-315.

40 Adeoye O，Sucharew H，Khoury J，et al. Combined

approach to lysis utilizing eptifibatide and recombinant

tissue-type plasminogen activator in acute ischemic

stroke-full dose regimen stroke trial[J]. Stroke，2015，

46：2529-2533.

41 Fransen PS，Beumer D，Berkhemer OA，et al.

MRCLEAN，a multicenter randomized clinical trialof endovascular treatment for acute ischemic stroke

in the Netherlands：study protocol for a randomized

controlled trial[J]. Trials，2014，15：343.

42 Goya l M，Demchu k AM，Menon BK，e t a l .

Randomized assessment of rapid endovascular

treatment of ischemic stroke[J]. N Engl J Med，2015，

372：1019-1030.

43 Campbell BC，Mitchell PJ，Yan B，et al. A multicenter，

randomized，controlled study to investigate EXtending

the time for Thrombolysis in Emergency Neurological

Deficits with Intra-Arterial therapy (EXTEND-I)[J]. In

J Stroke，2014，9：126-132.

44 Qu r e s h i A I，Si dd i qu i AM，Kim SH，e t a l .

Reocclusion of recanalized arteries during intraarterial

thrombolysis for acute ischemic stroke[J].

AJNR Am J Neuroradiol，2004，25：322-328.

45 Heo JH，Lee KY，Kim SH，et al. Immediate

reocclusion following a successful thrombolysis in

acute stroke：a pilot study[J]. Neurology，2003，60：

1684-1687.

46 Janjua N，Alkawi A，Suri MF，et al. Impact of

arterial reocclusion and distal fragmentation during

thrombolysis among patients with acute ischemic

stroke[J]. AJNR Am J Neuroradiol，2008，29：253-

258.

47 Ries T，Siemonsen S，Grzyska U，et al. Abciximab

is a safe rescue therapy in thromboembolic events

complicating cerebral aneurysm coil embolization：

single center experience in 42 cases and review of the

literature[J]. Stroke，2009，40：1750-1757.

48 Saedon M，Singer DR，Pang R，et al. Registry report

on kinetics of rescue antiplatelet treatment to abolish

cerebral microemboli after carotid endarterectomy[J].

Stroke，2013，44：230-233.

49 Velat GJ，Burry MV，Eskioglu E，et al. The use

of abciximab in the treatment of acute cerebral

thromboembolic events during neuroendovascular

procedures[J]. Surg Neurol，2006，65：352-358，

discussion 358-359.

50 Kim JW，Jeon P，Kim GM，et al. Local intraarterial

tirofiban after formation of anterograde f low in

patients with acute ischemic stroke：preliminary

experience and short term follow-up results[J]. Clin

Neurol Neurosurg，2012，114：1316-1319.

51 Seo JH，Jeong HW，Kim ST，et al. Adjuvant tirofiban

injection through deployed solitaire stent as arescue

technique after failed mechanical thrombectomy in

acute stroke[J]. Neurointervention，2015，10：22-27.

52 中华医学会神经病学分会，中华医学会神经病学分会

神经血管介入协作组，急性缺血性卒中介入诊疗指南

撰写组. 中国急性缺血性卒中早期血管内介入诊疗指

南[J]. 中国神经科杂志，2015，48：356-361.