关键词: 脑梗死; 脑白质病变; 认知障碍; 量表

Abstract: Objective To investigate the correlation between the cognitive impairment and leukoaraiosis inpatients with acute ischemic stroke.Methods One hundred and seven emergency patients with acute ischemic stroke (onset within 7days) were included in this study. The cognitive function was assessed with Montreal CognitiveAssessment (MoCA). Two trained raters evaluated computer tomography (CT) and magneticresonance imaging (MRI) scans using CT(Blennow) and MRI (Fazekas and CholinergicPathways HyperIntensities Scale [CHIPS]) rating scales for white matter changes. Correlationsbetween the cognitive impairment and leukoaraiosis were evaluated.Results High correlations were observed between MoCA and Blennow and CHIPS rating scales(Spearman’s coefficient were-0.300 and-0.316, respectively, P <0.01). There was no significantcorrelation between MoCA and Fazekas rating scale (Spearman’s coefficient was-0.159, P >0.05).Conclusion The present findings support the view that a good correlation exists between thecognitive impairment and severity of white matter changes in patients with acute ischemic stroke.The MRI rating scale for white matter lesions, in cholinergic pathways, CHIPS rating scale, iseffective, reliable and shows stronger correlations with cognitive performance.

Key words: Brain infarction; White matter lesion; Cognitive disorders; Rating scales