线粒体自噬在蛛网膜下腔出血中的研究进展

doi:10.3969/j.issn.1673-5765.2021.07.019

摘要/Abstract

摘要： 线粒体自噬为选择性自噬的一种，在生理状态下、各种急性应激及慢性疾病中，主要参与了线粒体稳态的调节、受损线粒体的清除及避免细胞死亡等多种细胞内生理性反应过程。在多种神经疾病过程中可见到线粒体自噬的参与，但关于线粒体自噬在蛛网膜下腔出血中的研究较少，本文从线粒体自噬的经典通路、在蛛网膜下腔出血中的作用机制及对预后的影响等方面进行了综述。

文章导读： 本文介绍了线粒体自噬依赖/不依赖泛素的两种经典通路；线粒体形态改变（通过融合/分裂）可激活/
抑制线粒体自噬从而调控细胞的存活或死亡；在SAH中通过促进线粒体自噬可改善患者预后。

关键词: 线粒体自噬; 蛛网膜下腔出血; 自噬; 凋亡

Abstract: As a kind of selective autophagy, mitophagy is mainly involved in the regulation of mitochondrial homeostasis, the removal of damaged mitochondria and the prevention of cell death under physiological conditions, various acute stress and chronic diseases. Mitophagy is also involved in multiple neurological diseases. However, there are few studies about the role of mitophagy in subarachnoid hemorrhage. This article reviewed the classic pathways of mitophagy, the mechanism of mitophagy action in subarachnoid hemorrhage, and the impact on the prognosis.

Key words: Mitophagy; Subarachnoid hemorrhage; Autophagy; Apoptosis

张永智, 刘彬冰, 田杨, 史怀璋. 线粒体自噬在蛛网膜下腔出血中的研究进展[J]. 中国卒中杂志, 2021, 16(07): 752-756.

ZHANG Yong-Zhi, LIU Bin-Bing, TIAN Yang, SHI Huai-Zhang. Progress of Mitophagy in Subarachnoid Hemorrhage[J]. Chinese Journal of Stroke, 2021, 16(07): 752-756.

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