关键词: 阿司匹林抵抗; 脑小血管病; 预后

Abstract:

Objective To explore the incidence of aspirin resistance (AR), and the relationship between AR and 2-year outcome in patients with cerebral small vessel disease (CSVD). Methods This prospective study enrolled consecutive patients diagnosed with CSVD in Department of Neurology from August 2015 to June 2017. The patients were divided into aspirin resistance (AR) group and non-aspirin resistance (non-AR) group according to the platelet inhibition rate measured by thromboelastography. Baseline data included demographic information, laboratory tests and imaging results. The outcomes were evaluated by recording new-onset vascular events and imaging re-examination within 2-year follow-up. Multivariate logistic regression analysis was used to determine the correlation between AR and outcome. Results A total of 94 CSVD patients were included, with the mean age of 66.20±7.37 years (range: 49-84 years), and 55 males (58.5%). The total incidence of AR was 23.4% (22/94). AR was associated with the risk of new-onset lacunar infarction (OR 4.70, 95%CI 1.56-24.13, P =0.041) and white matter lesions progression (OR 4.07, 95%CI 1.28-11.57, P =0.038), and not associated with the risk of new-onset vascular events and mortality within 2 years. Conclusions The incidence of AR in CSVD in-hospital patients was about one fifth. AR may be associated with the risk of new-onset lacunar infarction and white matter lesions progression.

Key words: Aspirin resistance; Cerebral small vessel disease; Prognosis