关键词: 纤溶酶原激活剂; 血栓溶解疗法; 血压; 预后

Abstract: Objective To investigate the relationship between the clinical outcomes of thrombolysis treatmentusing recombinant tissue plasminogen activator (rt-PA) in patients with ultra-acute cerebralinfarction and the changes of systolic pressure in 24h and 72h after treatment.Methods One hundred and twelve patients with ultra-acute cerebral infarction treated byintravenous rt-PA were assigned to the poor outcome group[90d modified Rankin Score (mRS) 2-5]and the good outcome group (90d mRS 0-1). The changes of systolic pressure of enrolled patientswere recorded at time of pre-treatment and 24h and 72h post-treatment respectively. Then thesechanges were compared between two groups.Results The decreases of systolic pressure in 24h after treatment in poor outcome group was (7±8)mmHg, comparing with the (10±8) mmHg in good outcome group. There was a statisticallysignificant difference (t =-2.20, P =0.032) of systolic blood pressure variety between the two groups.The decreases of systolic pressure in 72h post-treatment in the two groups were (8±8)mmHg and(10±8)mmHg respectively. There was not a statistically significant difference (t =-1.52, P =0.13)between two groups.Conclusion The descending of systolic blood pressure in 24h after thrombolysis treatment ingood outcomes group was more obvious than that in poor outcomes group. But this difference didnot appear in 72h post-treatment. The degree of the systolic pressure decreasing in 24h after rt-PAthrombolysis potentially was related positively with benign prognosis after 90d.

Key words: Plasminogen activators; Thrombolytic therapy; Blood pressure; Prognosis