焦虑症患者临床治愈前后脑血流调节的变化

摘要/Abstract

摘要：

【摘要】目的分析焦虑症患者临床治愈前后脑血流调节的变化。方法应用经颅多普勒超声（transcranial Doppler，TCD）卧-立位脑血流检测方法分析50例焦虑症患者在体位变化时脑血流速度的变化特点并与健康对照组比较，然后随访6个月，观察焦虑症治愈组与未愈组TCD卧-立位脑血流变化。结果焦虑症组较对照组立位时脑血流速度下降（P <0.001），卧-立位脑血流差值大于对照组（P <0.001）；随访发现，焦虑症治愈组治疗后较治疗前卧-立位脑血流差值减小（P <0.001），可恢复到对照组水平；焦虑症未愈组治疗后卧-立位脑血流差值仍大于对照组（P =0.007）；治疗后治愈组卧-立位脑血流差值较未愈组减小（P =0.003）。结论 TCD卧-立位脑血流检测显示，焦虑症患者存在脑血流调节的异常，而且在焦虑症临床治愈后，脑血流调节可恢复正常。

文章导读： 本研究应用经颅多普勒超声检查，显示焦虑症患者立位脑血流速度低于健康人群，卧-立位脑血
流速度差值大于健康者，焦虑症治愈后较治疗前卧-立位脑血流速度差值减小。

关键词: 焦虑症; 脑血流调节功能; 经颅多普勒超声

Abstract:

【Abstract】 Objective To study cerebral blood flow regulation features in patients with anxiety before and after treatment. Methods Subjects with Hamilton anxiety scale scores ≥14 were enrolled, and the dynamic changes in their cerebral blood flow velocity (CBFV) in response to an orthostatic challenge were investigated using transcranial Doppler. Next, we provided the patients with treatment, and then they were followed-up for a period of 6 months. The dynamic changes in their CBFV values were then re-recorded. Results The CBFV changes from supine to upright differed between the anxious and the healthy groups. Anxious subjects showed more pronounced decreases in CBFV with abrupt standing (P <0.001). In the recovery group, the changes in the mean CBFV values from the supine to the upright position were significantly improved after treatment (P <0.001), and can restore to the healthy group level. Conclusion Our results indicate that cerebral blood flow regulation is compromised in anxiety; however, it can restore to normal after the disappearance of anxiety.

Key words: Anxiety; Cerebral blood flow regulation; Transcranial Doppler

邢英琦1，郭珍妮1，杨乐2，闫硕2，杨弋2. 焦虑症患者临床治愈前后脑血流调节的变化[J]. 中国卒中杂志, 2014, 9(03): 183-187.

XING Ying-Qi*, GUO Zhen-Ni, YANG Le, YAN Shuo, YANG Yi.. Changes in Cerebrovascular Modulation in Anxiety before and after Treatment[J]. Chinese Journal of Stroke, 2014, 9(03): 183-187.

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