1 Adams HP Jr, Bendixen BH, Kappelle LJ, et

al. Classif ication of subtype of acute ischemic

stroke. Definitions for use in a multicenter clinical

trial. TOAST. Trial of Org 10172 in Acute Stroke

Treatment[J]. Stroke, 1993, 24:35-41.

2 Caplan LR. Kaplan's Stroke:A Clinical Approach[M].

Boston:Butterworth Heinemann, 2000:247-282.

3 Palacio S, Hart RG. Neurologic manifestations of

cardiogenic embolism:an update[J]. Neurol Clin, 2002,

20:179-193.

4 Caplan LR. Cerebrovascular disease and neurologic

ma n i f e s t a t i o n s of h e a r t d i s e a s e s [M] . New

York:McGraw-Hill, 2001:173.

5 Tomsick TA, Brot t TG, Chambe r s AA, et al.

Hyperdense middle cerebral artery sign on CT:efficacy

in detecting middle cerebral artery thrombosis[J].

AJNR Am J Neuroradiol, 1990, 11:473-477.

6 Ferro JM. Cardioembolic stroke:an update[J]. Lancet

Neurol, 2003, 2:177-188.

7 Kittner SJ, Sharkness CM, Price TR, et al. Infarcts

with a cardiac source of embolism in the NINCDS

Stroke Data Bank:historical features[J]. Neurology,

1990, 40:281-284.

8 Bogousslavsky J, Cachin C, Regli F, et al. Cardiac

sources of embolism and cerebral infarction--clinical

consequences and vascular concomitants:the Lausanne

Stroke Registry[J]. Neurology, 1991, 41:855-859.

9 Roh JK, Kang DW, Lee SH, et al. Significance of

acute multiple brain infarction on diffusion-weighted

imaging[J]. Stroke, 2000, 31:688-694.

10 Wessels T, Wessels C, Ellsiepen A, et al. Contribution of

diffusion-weighted imaging in determination of stroke

etiology[J]. AJNR Am J Neuroradiol, 2006, 27:35-39.

11 Caplan LR, ManningW. Brain Embolism[M]. New

York:Informa Healthcare, 2006:129-151.

12 Ferro JM. Brain embolism - Answers to practical

questions[J]. J Neurol, 2003, 250:139-147.

13 Murtagh B, Smalling RW. Cardioembolic stroke[J].

Curr Atheroscler Rep, 2006, 8:310-316.

14 Kittner SJ, Sharkness CM, Sloan MA, et al. Infarcts

with a cardiac source of embolism in the NINDS

St roke Dat a Ban k:neurologic examinat ion[J ].

Neurology, 1992, 42:299-302.

15 Jung DK, Dev uyst G, Maeder P, et al. At r ial

fibrillation with small subcortical infarcts[J]. J Neurol

Neurosurg Psychiatry, 2001, 70:344-349.

16 Knipp SC, Matatko N, Schlamann M, et al. Small

ischemic brain lesions after cardiac valve replacement

detected by diffusion-weighted magnetic resonance

imaging:relation to neurocognitive function[J]. Eur J

Cardiothorac Surg, 2005, 28:88-96.

17 Lodder J, Krijne-Kubat B, Broekman J. Cerebral

hemorrhagic infarction at autopsy:cardiac embolic cause and the relationship to the cause of death[J].

Stroke, 1986, 17:626-629.

18 Bladin CF. Seizures after stroke[D]. Melbourne:

University of Melbourne, Australia, 1997.

19 Timsit SG, Sacco RL, Mohr JP, et al. Brain infarction

severity differs according to cardiac or arterial

embolic source[J]. Neurology, 1993, 43:728-733.

20 Kim YD, Hong HJ, Cha MJ, et al. Determinants of

infarction patterns in cardioembolic stroke[J]. Eur

Neurol, 2011, 66:145-150.

21 Wessels T, Röttger C, Jauss M, et al. Identification of

embolic stroke patterns by diffusion-weighted MRI in

clinically defined lacunar stroke syndromes[J]. Stroke,

2005, 36:757-761.

22 Kim BJ, Sohn H, Sun BJ, et al. Imaging characteristics

of ischemic strokes related to patent foramen ovale[J].

Stroke, 2013, 44:3350-3356.

23 Ruttmann E, Willeit J, Ulmer H, et al. Neurological

outcome of septic cardioembolic stroke after infective

endocarditis[J]. Stroke, 2006, 37:2094-2099.

24 Vassallo R, Remstein ED, Parisi JE, et al. Multiple

cerebral infarctions from nonbacterial thrombotic

endocarditis mimicking cerebral vasculitis[J]. Mayo

Clin Proc, 1999, 74:798-802.

25 Singhal AB, Topcuoglu MA, Buonanno FS. Acute

ischemic stroke patterns in infective and nonbacterial

thrombot ic endocardit is:a diffusion-weighted

magnetic resonance imaging study[J]. Stroke, 2002,

33:1267-1273.

26 Fisher C, Adams R. Observations on brain embolism

with special reference to hemorrhagic infarction[J]. J

Neuropathol Exp Neurol, 1951, 10:92-94.

27 Molina CA, Montaner J, Abilleira S, et al. Timing of

spontaneous recanalization and risk of hemorrhagic

transformation in acute cardioembolic stroke[J].

Stroke, 2001, 32:1079-1084.

28 Moulin T, Crépin-Leblond T, Chopard JL, et al.

Hemorrhagic infarcts[J]. Eur Neurol, 1994, 34:64-77.

29 Yamaguchi T, Minematsu K, Choki J, et al. Clinical and

neuroradiological analysis of thrombotic and embolic

cerebral infarction[J]. Jpn Circ J, 1984, 48:50-58.

30 Pessin MS, Estol CJ, Lafranchise F, et al. Safety

of anticoagulation after hemorrhagic infarction[J].

Neurology, 1993, 43:1298-1303.

31 Chaves CJ, Pessin MS, Caplan LR, et al. Cerebellar

hemorrhagic infarction[J]. Neurology, 1996, 46:346-349.

32 Moriya Y, Takahashi W, Kijima C, et al. Predictors for

hemorrhagic transformation with intravenous tissue

plasminogen activator in acute ischemic stroke[J].

Tokai J Exp Clin Med, 2013, 38:24-27.

33 Schell inger PD, Chalela JA, Kang DW, et al.

Diagnost ic and prognost ic value of ea rly MR

imaging vessel signs in hyperacute stroke patients

imaged <3 hours and treated with recombinant tissue

plasminogen activator[J]. AJNR Am J Neuroradiol,

2005, 26:618-624.

34 Cho KH, Kim JS, Kwon SU, et al. Significance of

susceptibility vessel sign on T2*-weighted gradient

echo imaging for identification of stroke subtypes[J].

Stroke, 2005, 36:2379-2383.

35 Nighoghossian N, Hermier M, Adeleine P, et al. Old

microbleeds are a potential risk factor for cerebral

bleeding after ischemic stroke:a gradient-echo T2*-

weighted brain MRI study[J]. Stroke, 2002, 33:735-742.

36 Liu JR, Plötz BM, Rohr A, et al. Association of

right-to-left shunt with frontal white matter lesions

in T2-weighted MR imaging of stroke patients[J].

Neuroradiology, 2009, 51:299-304.

37 宁斌, 何文, 项东英, 等. 卵圆孔未闭和卒中的关系[J].

中国卒中杂志, 2011, 6:469-472.

38 Kang DW, Chalela JA, Ez zeddine MA, et al.

Association of ischemic lesion patterns on early

diffusion-weighted imaging with TOAST stroke

subtypes[J]. Arch Neurol, 2003, 60:1730-1734.

39 Vermeer SE, Prins ND, den Heijer T, et al. Silent

brain infarcts and the risk of dementia and cognitive

decline[J]. N Engl J Med, 2003, 348:1215-1222.

40 Giele JL, Witkamp TD, Mali WP, et al. Silent brain

infarcts in patients with manifest vascular disease[J].

Stroke, 2004, 35:742-746.

41 Kovács KR, Czuriga D, Bereczki D, et al. Silent brain

infarction--a review of recent observations[J]. Int J

Stroke, 2013, 8:334-347.

42 Braemswig TB, Usnich T, Albach FN, et al. Early

new diffusion-weighted imaging lesions appear more

often in stroke patients with a multiple territory lesion

pattern[J]. Stroke, 2013, 44:2200-2204.

43 Kim SJ, Shin HY, Ha YS, et al. Paradoxical embolism

as a cause of silent brain infarctions in healthy

subjects:the ICONS study (Identification of the Cause

of Silent Cerebral Infarction in Healthy Subjects)[J].

Eur J Neurol, 2013, 20:353-360.