关键词: 脑小血管病; 初筛; 数字眼底照相; 眼底血管改变; 颈动脉斑块。

Abstract:

Objective To explore digital fundus photography technology applications in clinical screening of cerebral small vessel disease (CSVD), so as to provide basis for community clinical primary screening of CSVD. Methods A total of 36 cases (72 eyes) of patients who were diagnosed as CSVD from April 2015 to April 2016 were selected as the observation group, and the other 30 cases (60 eyes) of the healthy volunteers who had normal head MRI results in the same time were selected as control group. There were statistical comparisons of general clinical information, fundus changes and carotid plaque between the two groups. Results Compared with control group, in the observation group, incidence of arteriovenous crossing sign (77.78% vs 23.33%), total incidence of fundus changes (88.89% vs 56.67%), and retinal arteriosclerosis grade 3 (30.56% vs 0) were higher (P <0.001, P =0.003, P =0.002). Logistic multivariate regression analysis showed that, arteriovenous crossing sign was an important risk factor of CSVD (odds ratio[OR] 10.678, 95% confidence interval[CI ] 2.943-38.742, P <0.001). In the observation group, the incidence of carotid plaque and the average of carotid plaque of patients with fundus changes (n =32) were higher than that of patients without fundus changes (n =4) (P =0.01, P =0.013). Conclusion In the study, more than half of CSVD patients with arteriovenous crossing sign, and digital ocular fundus photography may be used as one of the CSVD clinical primary screening methods.

Key words: Cerebral small vessel disease; Primary screening; Digital ocular fundus photography; Fundus changes; Carotid plaques