中国卒中杂志 ›› 2017, Vol. 12 ›› Issue (01): 80-84.DOI: 10.3969/j.issn.1673-5765.2017.01.016

• 综述 • 上一篇    下一篇

蛛网膜下腔出血后线粒体钙超载形成机制的研究进展

张彤宇,李俞辰,戴家兴,吴培,王永朋,史怀璋   

  1. 150001 哈尔滨哈尔滨医科大学附属第一医院神经外科三病房
  • 收稿日期:2016-05-30 出版日期:2017-01-20 发布日期:2017-01-20
  • 通讯作者: 史怀璋huaizhangshi@163.com
  • 基金资助:

    国家青年科学基金项目(81100854)
    黑龙江省中医药科研项目(ZHY12-Z174)

Advance in the Forming Mechanism of Mitochondrial Calcium Overloaded after Subarachnoid Hemorrhage

  • Received:2016-05-30 Online:2017-01-20 Published:2017-01-20

摘要:

线粒体钙超载(mitochondrial calcium overloaded)情况下,Ca2+在细胞线粒体中浓度异常增高, 可引起一系列生物系统紊乱,进而导致细胞的不可逆性损伤。这一过程广泛存在于蛛网膜下腔出血 (subarachnoid hemorrhage,SAH)后导致的早期脑损害(early brain injury,EBI)中。虽然我们对线粒体的 分子结构有所了解,但对于线粒体钙超载发生过程中的分子机制仍知之甚少。本文主要就线粒体钙 超载形成过程中各线粒体膜受体发挥的不同作用机制的研究进展情况做一综述,以期为针对SAH后 的EBI保护提供参考。

文章导读: 本文对于蛛网膜下腔出血中线粒体钙超载形成机制,以线粒体不同膜受体可能存在的作用及机制相关研究为着眼点分类进行了系统的综述。

关键词: 线粒体钙超载; 蛛网膜下腔出血; 早期脑损害

Abstract:

Under the condition of mitochondrial calcium overloaded, Ca2+ concentration in the mitochondria of cells increases abnormally which leads to a series of biological systemic disorder and causes the irreversibility of cell damage. This process widely exists in the early brain injury (EBI) caused by subarachnoid hemorrhage (SAH). We have understood the molecular structure of the mitochondria, but the knowledge about the molecular mechanisms of mitochondrial calcium overloaded is still little. Therefore, in this review we aim to discuss the progress of the mechanisms of the mitochondrial membrane receptors in the forming process of mitochondrial calcium overloaded. And it will give reference for solving the problem of EBI after SAH.

Key words: Mitochondrial calcium overloaded; Subarachnoid hemorrhage; Early brain injury