血栓形成中的凝血与免疫

doi:10.3969/j.issn.1673-5765.2020.01.008

摘要/Abstract

摘要：

血栓形成是血管损伤后血小板活化、凝血因子激活导致凝血的过程，研究表明凝血和炎症之间存在广泛的联系，涉及血液级联系统、免疫细胞和血管内皮细胞之间的相互作用。血小板、组织因子、凝血酶、接触激活系统、补体系统在促进血栓形成过程启动促炎反应，纤溶酶原激活系统在激活纤溶的同时促进与血栓形成有关的炎症过程，这些综合因素最终导致血栓-炎症的产生。本文就凝血与免疫的关系及其在血栓形成中的作用作简要的阐述，旨在为今后研究炎症和血栓性疾病的治疗靶点提供思路。

文章导读： 凝血和免疫在血栓的形成中密切相关，本文综述了凝血-免疫在血栓形成中的相互作用，为抗栓治疗策略的研究提供参考。

关键词: 凝血; 免疫; 血栓

Abstract:

Thrombosis is the result of blood coagulation caused by platelet and coagulation factor activation after vascular injury. Studies have shown that there are extensive links between coagulation and inflammation, involving the interaction among the blood cascade system, immune cells and vascular endothelial cells. Platelets, tissue factors, thrombin, contact activation system and complement system jointly promote thrombosis, and activated proinflammatory responses. Plasminogen activation system not only activates fibrinolysis but also promotes the inflammatory process associated with thrombosis. These pathophysiological reactions ultimately lead to thromboinflammation process. This article introduced the relationship between coagulation and immune and the role of immune in thrombosis, to provide reference for the future research on therapeutic targets for inflammatory and thrombotic diseases.

Key words: Coagulation; Immune; Thrombosis

张薇，阎涛. 血栓形成中的凝血与免疫[J]. 中国卒中杂志, 2020, 15(01): 51-56.

ZHANG Wei, YAN Tao. Coagulation and Immune in Thrombosis[J]. Chinese Journal of Stroke, 2020, 15(01): 51-56.

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