中国卒中杂志 ›› 2020, Vol. 15 ›› Issue (01): 98-101.DOI: 10.3969/j.issn.1673-5765.2020.01.016

• 综述 • 上一篇    下一篇

癫痫的脑血流动力学研究进展

孔朝红,王群   

  1. 100070 北京首都医科大学附属北京天坛医院神经病学中心
  • 收稿日期:2018-09-06 出版日期:2020-01-20 发布日期:2020-01-20
  • 通讯作者: 王群 wangq@ccmu.edu.cn
  • 基金资助:

    首都卫生发展科研专项重点攻关项目(2016-1-2011)

Progress of Cerebral Hemodynamics in Epilepsy

  • Received:2018-09-06 Online:2020-01-20 Published:2020-01-20

摘要:

癫痫不同发作阶段脑组织的局部会有不同的血流变化:发作期,癫痫灶内血流量增快、 神经组织代谢率增高;间歇期,癫痫灶内血流量减慢、神经组织代谢率降低。研究癫痫不同阶段的 脑血流变化特点,可能为癫痫的研究提供一条新的思路。近年来有关癫痫脑血流动力学的研究一直 未被重视。本文就癫痫的脑血流动力学变化特点及可能的机制做一简要综述。

文章导读: 癫痫的脑血流动力学特点及机制尚未完全阐明,探寻其不同阶段的血流动力学的特点及机制对于新形势下癫痫防治措施的制订有着重要的意义。

关键词: 癫痫; 血流动力学; 神经影像; 反相灌注

Abstract:

There are different changes of cerebral blood flow in different stages of epileptic seizure. During epileptic seizure, cerebral blood flow increased and brain tissue metabolic rate increased in epileptic focus; while during the intermittent period, cerebral blood flow slowed and brain tissue metabolic rate decreased. It is of great significance to study the characteristics of cerebral blood flow changes in epileptic focus in different stages of epileptic seizures, which will help to elucidate the pathogenesis of seizure. This article reviewed the progress in cerebral hemodynamics and possible mechanism of epilepsy.

Key words: Epilepsy; Hemodynamics; Neuroimaging; Reverse perfusion