依达拉奉对认知障碍作用的研究进展

doi:10.3969/j.issn.1673-5765.2020.03.019

摘要/Abstract

摘要：

依达拉奉是一种自由基清除剂，具有神经保护作用。目前的研究认为，依达拉奉改善血管性认知障碍的机制可能与以下因素有关：清除自由基，抑制氧化应激；促进海马中神经营养因子的表达；抑制缺血诱导的海马钙-钙调蛋白依赖性蛋白激酶II的失活，增加海马齿状回颗粒细胞下区双皮质素阳性神经元前体细胞数；通过抑制炎症反应，抑制星形胶质细胞活化，保护海马；抑制神经细胞凋亡。依达拉奉能改善阿尔茨海默病患者的认知障碍，其机制可能与减少β-淀粉样蛋白沉积，抑制Tau蛋白过度磷酸化，增强氧自由基代谢能力、降低氧化应激和炎性反应，增强突触功能等有关。此外，依达拉奉也可能对术后认知功能障碍、创伤性脑损伤后认知功能障碍、脑室内出血以及慢性束缚应激诱导的认知障碍有改善作用。

文章导读： 动物实验和临床研究提示依达拉奉可以通过多种机制改善脑缺血缺氧导致的认知功能障碍，而且在改善创伤、手术、阿尔茨海默病等多种病因导致的认知障碍方面也有潜在应用价值。

关键词: 依达拉奉; 认知障碍; 脑缺血; 阿尔茨海默病; 氧化应激

Abstract:

Edaravone (Eda) is a free radical scavenger with neuroprotective effects. The mechanism of Eda to improve vascular cognitive impairment may be related to the following factors: scavenge free radicals and inhibit oxidative stress; promote the expression of brain-derived neurotrophic factors in the hippocampus; suppress ischemia-induced inactivation of calciumcalmodulin- dependent protein kinase II in the hippocampus, increase the number of doublecortinpositive neuronal precursor cells in the dentate gyrus subgranular zone; protect the hippocampus by inhibiting inflammatory responses and astrocyte activation; inhibit neuronal apoptosis. Eda can improve the cognitive impairment in patients with Alzheimer's disease, and the relevant mechanisms include that Eda can reduce amyloid-β deposition, inhibit Tau protein hyperphosphorylation, enhance oxygen free radical metabolism, reduce oxidative stress and inflammatory response and enhance synaptic function. Moreover, Eda can also improve postoperative cognitive dysfunction, cognitive impairment after traumatic brain injury, cognitive impairment after intraventricular hemorrhage and chronic restraint stress-induced cognitive deficit.

Key words: Edaravone; Cognition impairment; Ischemic brain injury; Alzheimer's disease;Oxidative stress

许墨菊，李战永. 依达拉奉对认知障碍作用的研究进展[J]. 中国卒中杂志, 2020, 15(03): 326-331.

XU Mo-Ju, LI Zhan-Yong. Progress of the Effect of Edaravone on Cognitive Impairment[J]. Chinese Journal of Stroke, 2020, 15(03): 326-331.

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