DNA甲基化酶3A在动脉粥样硬化中的作用机制

doi:10.3969/j.issn.1673-5765.2021.11.016

摘要/Abstract

摘要： 近来的研究显示，DNA甲基化酶3A（DNA methylase 3 alpha，DNMT3A）在动脉粥样硬化过程中起着重要的调控作用，而动脉粥样硬化是冠心病及缺血性卒中等心脑血管疾病的重要病理基础。体细胞DNMT3A 基因突变可能通过多种免疫细胞、作用机制影响动脉粥样硬化的发生、发展过程，是心脑血管疾病一项尚未明确的重要危险因素。本文重点介绍DNMT3A在心脑血管疾病中的作用机制以及其在心脑血管疾病诊疗中的应用前景。

文章导读： DNMT3A 基因是CHIP中的热点突变之一，可通过多种作用影响动脉粥样硬化，进而造成心脑血管疾病的发
生、发展。目前关于DNMT3A 基因突变在动脉粥样硬化中的作用机制的研究尚处于初期阶段，需要进一步的研究
明确其作用通路。

关键词: DNA甲基化酶3A; 动脉粥样硬化; 心脑血管病; 作用机制; 炎症

Abstract: DNA methylase 3 alpha (DNMT3A) is an important DNA methylation enzyme. Recent studies have shown that it plays an important role in the regulation of atherosclerosis, which is the important pathological basis of cardiovascular and cerebrovascular diseases (CVD), such as coronary heart disease and ischemic stroke. Somatic DNMT3A mutation may affect the occurrence and development of atherosclerosis through several immune cells and mechanisms, and it is an important risk factor for CVD that has not been fully studied. This article focused on the mechanism of DNMT3A in CVD and its application prospect in the diagnosis and treatment of CVD.

Key words: DNMT3A; Atherosclerosis; Cardiovascular and cerebrovascular disease; Mechanism; Inflammation

闫然, 上官艺, 仇鑫, 李子孝. DNA甲基化酶3A在动脉粥样硬化中的作用机制[J]. 中国卒中杂志, 2021, 16(11): 1178-1182.

YAN Ran, SHANGGUAN Yi, QIU Xin, LI Zi-Xiao. Mechanism of DNMT3A in Atherosclerosis[J]. Chinese Journal of Stroke, 2021, 16(11): 1178-1182.

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