关键词: 高原; 急性脑梗死; 老年男性; 雄激素; 睾酮; 血脂; 细胞因子

Abstract: Objective To study the relationship between androgen levels and acute cerebral infarction(ACI) inelderly men at high altitude.Methods Serum levels of testosterone(T) and estradiol (E2)were determined in 60 elderly menwith ACI and 60 healthy elderly men at high altitude (2260 m sea levels above). Serum levels ofinterleukin(IL)-1, IL-6, tumor necrosis factor(TNF)-α and erythropoietin (EPO) were measuredby radioimmunoassay. We also measured the serum levels of triglyeride (TG), total cholesterol(TC), low-density lipoprotein (LDL), high density lipoprotein (HDL), apolipoprotein (Apo)-A1 andApo-B by colorimetry.Results (1) T was significantly lower in patients than in control subjects at high altitude (P <0.001).There was no statistical difference between patients and control subjects in E2, TC, HDL andApo-A1 levels. Compared with control subjects, the levels of TG, LDL and Apo-B in patientswere significantly higher (P <0.05). (2) Serum levels of IL-1β, IL-6 and TNF-α were increasedsignificantly in patients when compared with control subjects. EPO remained no significantdifference in two subjects at high altitude. (3) T was significantly negatively correlated with TG,LDL, Apo-B, TNF-α, IL-1 and IL-6. However, there was no correlated between E2, TC, HDL,Apo-A1, EPO and T.Conclusion These results support the idea that low T level is a risk factor of acute cerebralinfarction in men at high altitude, maybe by influencing upon lipid metabolism and inflammation.

Key words: High altitude; Acute cerebral infarction; Elderly men; Androgen; Testosterone; Lipids; Cytokine