关键词: 脑梗死; 急性; 代谢综合征; 预后; 多因素

Abstract: Objective To investigate the factors that may affect the prognosis of acute ischemic stroke in earlustage and to identify whether metabolic syndrome(MS) has an independent effect on the prognosisof acute stroke in early stage.Methods This was a prospective study. From June 1st,2005 to June 1st, 2006, 163 consecutivepatients with acute ischemic cerebral infarctions (<72 hours) were included in the study. Within 24hours of admission, National Institutes of Health Stroke Scale (NIHSS) and Glasgow Coma Scale(GCS) were evaluated; 1 month post stroke, Modified Rankin Scales (mRS) were done. Based onthe clinical presentation and physical examination, strokes were classified according to the TOAST(Trial of Org 10172 in Acute Stroke Treatment) scale. Multivariate logistic regression model wasused to perform the statistical analysis.Results The patients were divided into two groups according to mRS of 1 month after onset.Between the two groups (mRS=0-2 or mRS=3-6), sex(P <0.05), smoking(P <0.05), NIHSS(P <0.01),GCS (P <0.01), TOAST(P <0.01), infection(P <0.01), heart failure(P <0.05), MS(P <0.01)weresignificantly different by single variable analysis. Binary logistic analysis showed thatMS(OR 3.869, 95%CI 1.542-9.711, P <0.01), NIHSS(OR 19.699, 95%CI 2.107-184.134, P <0.01),TOAST(OR 0.188, 95%CI 0.067-0.525, P <0.01) and infection (OR 2.950, 95%CI 1.202-7.238,P <0.05) were independent prognostic foutors for poor prognosis.Conclusion MS, NIHSS, TOAST and infection were the independent prognostic factors for pooroutcome in patients with acute ischemic strokes during the early stage.

Key words: Cerebral infarction; Acute; Metabolism syndrome; Prognosis; Multiple analysis