关键词: 缺血缺氧性; 脑; 受体; TrkA; 受体; TrkB

Abstract: Tyrosine kinase A(TrkA) and tyrosine kinase B(TrkB) are high-affinity receptors of neurotrophic factor, and they can protect the brain against hypoxic/ischemic injury via combining to their specific ligand (nerve growth factor, NGF and brain –derived neurotrophic factor, BDNF). In recent years, the relationship between TrkA and TrkB with cerebral hypoxic/ischemic injury has become a hot spot for many researchers. In this paper, we review the expression, function and mechanism of protection of TrkA and TrkB in cerebral hypoxic/ischemic injury.

Key words: Hypoxia-ischemia; brain; Receptor; tyrosine kinase A(TrkA); Receptor; tyrosine kinase B(TrkB)