关键词: 抑郁; 卒中后; 单相抑郁症; 5-HTTLPR; 基因多态性; 病因; 疗效

Abstract: Objective To investigate the possible association of serotonin transporter gene-linked polymorphic region(5-HTTLPR) and the etiopathogenisis as well as therapeutic effect of post-stroke depression(PSD) and unipolar depression(UD) in Chinese Han population.Methods 45 patients with PSD, 41 patients with UD and 149 healthy controls were enrolled in our case-control study. The genotypes and alleles of 5-HTTLPR were detected with PCR. Then the patients with PSD and UD were treated by fluoxetine for 12 weeks. The severity of symptoms and the responses to fluoxetine were rated by the Hamilton Rating Scale for Depression (HAMD-17) on baseline and the 12th weeks.Results There is no significant differences in genotype(S/S, S/L and L/L) and allele(S and L)frequencies of 5-HTTLPR among PSD, unipolar depression and control group. Patieons with S/S genotype had more severe symptoms than those with S/L and L/L. After 12 weeks of treatment,there are significant differences in genotype(S/S, S/L and L/L) and allele(S and L) frequencies of 5-HTTLPR between cured and uncured group.Conclusion 5-HTTLPR may not be associated with PSD and UD in the Chianese Han population.Patient with S/S genotype may be have the more server symptom. After 12 weeks of treatment,patients with S/S genotype and S allele frequency had lower rate of clinical recovery.

Key words: post-stroke depression; unipolar depression; serotonin transporter gene-linked polymorphic region(5-HTTLPR); polymorphism; etiopathogenisis; therapeutic effect