关键词: 超声检查; 介入性; 血管造影术; 数字减影; 组织病理学; 颈动脉; 动脉粥样硬化

Abstract: Objective To compare intravascular ultrasound(IVUS) with digital subtractive angiography(DSA) and histopathologic findings of the carotid artery in vitro, and evaluate the role of IVUS in the diagnosis and treatment of carotid atherosclerotic disease.Methods 14 cervical carotid arteries were obtained in 7 cadavers. The vessel specimen was connected to the closed tubing system and continuously infused by 40% glycerin. DSA and IVUS were performed during infusion. Pathological examination was done, and statistical analysis were ensued.Results In the 14 cadaver carotid artery specimen, 42 pictures of IVUS were obtained and at the same 42 location, pathological examination were also done. In IVUS, 15 cases of atherosclerosis were detected, which was compatible with pathological examination. Ulcerative plaque was suspected in one case during IVUS examination, but no obvious abnormality was detected by pathological examination. The sensitivity and specificity of IVUS were 88% and 96% respectively. While in DSA examination, the sensitivity of mild atherosclerosis was only 47%. In the measurement of vascular diameter, there were no significantly statistical difference between DSA, IVUS and pathological examination.Conclusion IVUS can clearly show the characteristics of atherosclerosis of carotid artery, it can provide precise measurement of vascular diameter, severity and length of stenosis. As detecting early carotid atherosclerotic disease, IVUS is a very useful supplement while compared with DSA.

Key words: Ultrasonography interwentional; Angiography; digital subtraction; Histopathology; Carotid artery; Atherosclerosis