关键词: 脑梗死; 脑白质疏松; 年龄因素

Abstract: Objective To investigate different degrees of white matter lesions on cognitive function in patientswith ischemic cerebrovascular disease.Methods Patients with ischemic cerebrovascular disease were consecutively included. Stroke riskfactors were recorded. Neuropsychological tests, such as the Montreal cognitive assessment(MoCA),were carried out. Age-related white matter changes rating scale(ARWMCRs) was used to semiquantitativescore white matter lesions following neuroimaging examination. According to theARWMCRs scores, patients were divided into three groups: mild, moderate and severe group. Thedifference of neuropsychology, neural electrophysiology and the ability of daily life were comparedamong the three groups.Results The moderate and severe groups got lower neuropsychological testing scores(P <0.01)compared with the mild group. Correlation analysis showed that white matter lesions had a negativerelationship with neuropsychological tests(MoCA)(r =-0.677, P <0.01).Conclusion White matter lesions impact patients with ischemic cerebrovascular disease incognitive function, the more serious of white matter lesions, the more significant decline incognitive function.

Key words: Brain infarction; Leukoaraiosis; Age factors