关键词: C反应蛋白; 急性缺血性卒中

Abstract:

Objective To investigate the regularity and clinical significance of high serum sensitivity C-reactive protein(hs-CRP) level in the first early acute cerebral infarction(ACI) patients with the different etiology and pathophysiology. Methods Four hundred and twenty-three patients were divided in accordance with the etiology and pathophysiology of Chinese Ischemic Stroke Subclassification(CISS). Serum hs-CRP levels within 7 days were detected and analysed by immune turbidimetry. Results In the different causes, cardiogenic stroke group has the highest hs-CRP level([8.09±4.47]mg/L), followed by the order of large artery atherosclerosis group([5.89±4.02]mg/L, other etiology group[5.21±4.64]mg/L), penetrating artery disease group([3.67±3.47]mg/L) and undetermined etiology group([2.83±4.40]mg/L), hs-CRP level of each group was significant different(F=7.905; P=0.015); The pathophysiology of thrombosis is different, hs-CRP level is not the same, order as follows:artery-to-artery embolism group([7.88±3.35]mg/L), multiple mechanisms group([5.88±3.50]mg/L), hypoperfusion/emboli clearance group([5.15±4.36]mg/L, penetrating artery group[4.48±3.88]mg/L), hs-CRP level of each group was significant different(F=15.821; P=0.013). Conclusion Hs-CRP levels were significant different in the first early acute cerebral infarction patients with the different etiology and pathophysiology.

Key words: C-reactive protein; Acute cerebral infarction