中国卒中杂志 ›› 2013, Vol. 8 ›› Issue (11): 927-932.

• 综述 • 上一篇    下一篇

过氧化物酶增殖物激活受体-γ在动脉粥样硬化及缺血再灌注炎症损伤中的作用的研究进展

杨源瑞,陈康宁   

  1. 400038 重庆
    重庆西南医院神经内科
  • 收稿日期:2013-05-14 出版日期:2013-11-20 发布日期:2013-11-20
  • 通讯作者: 陈康宁 ckn_640827@126.com
  • 基金资助:

    国家自然科学基金资助项目(81271672

Research Progress of Peroxisome Proliferator-activated Receptor-γ on Atherosclerosis and Ischemia-reperfusion Injury

  1. Department of Neurology, Southwest Hospital, Chongqing 400038, China
  • Received:2013-05-14 Online:2013-11-20 Published:2013-11-20

摘要:

过氧化物酶增殖物激活受体-γ(peroxisome proliferator-activated receptor-γ,PPAR-γ)是配体依赖性激活的核受体超家族成员之一,具有多种生物学作用。近年来研究发现,PPAR-γ在其激动剂作用下对动脉粥样硬化和缺血再灌注损伤具有保护作用,PPAR-γ有望成为治疗上述疾病的新靶标。本文就PPAR-γ对动脉粥样硬化和缺血再灌注损伤保护作用的相关研究进展做一综述。

文章导读: 本文通过对过氧化物酶增殖物激活受体-γ在动脉粥样硬化与缺血再灌注损伤中的作用的阐述,以期为改善脑动脉支架植入术后重构的探究提供新的线索。

关键词: 过氧化物酶增殖物激活受体-γ 动脉粥样硬化; 缺血再灌注损伤; 炎症

Abstract:

Peroxisome proliferator-activated receptor-γ (PPAR-γ) is a ligand-activated transcription factor belonging to the nuclear hormone receptor superfamily, which has many biological effects. In recent years, the studies have found that PPAR-γ has a protective effect on atherosclerosis and ischemia reperfusion injury under its agonist effect, and it might be expected to become the new targets for the treatment of the disease. This review focuses on the recent advances of PPAR-γ and its recognized effects on major inflammation diseases, in particular, atherosclerosis and cerebral ischemia/reperfusion (I/R) injury associated processes.

Key words: Peroxisome proliferator-activated receptor-γ; Atherosclerosis; Ischemia- reperfusion injury; Inflammation