1 Roger VL, Go AS, Lloyd-Jones DM, et al. Heartdisease and stroke statistics--2012 update:A reportfrom the American Heart Association[J]. Circulation,2012, 125:e2-e220.2 He J, Gu D, Wu X, et al. Major causes of death amongmen and women in China[J]. N Engl J Med, 2005,353:1124-1134.3 Zarins CK, Giddens DP, Bharadvaj BK, et al. Carotidbifurcation atherosclerosis:Quantitative correlationof plaque localization with flow velocity profiles andwall shear stress[J]. Circ Res, 1983, 53:502-514.4 Ku DN, Giddens DP, Zarins CK, et al. Pulsatilef low and atherosclerosis in the human carotidbifurcation:positive correlation between plaquelocation and low and oscillating shear stress[J].Atherosclerosis, 1985, 5:293-302.5 Glagov S, Zarins C, Giddens DP, et al. Hemodynamicsand atherosclerosis. Insights and perspectives gainedfrom studies of human arteries[J]. Arch Pathol LabMed, 1988, 112:1018-1031.6 Xue YJ, Gao PY, Duan Q, et al. Preliminary study ofhemodynamic distribution in patient-specific stenoticcarotid bifurcation by image-based computationalfluid dynamics[J]. Acta Radiol, 2008, 49:558-565.7 Pen nathu r S, Be rg t C, Shao B, et al. Humanatherosclerotic intima and blood of patients withestablished coronary artery disease contain highdensity lipoprotein damaged by reactive nitrogenspecies[J]. J Biol Chem, 2004, 279:42977-42983. 8 杨永宗. 动脉粥样硬化性心血管病基础与临床[M]. 北京:科学出版社, 2004:3-9.9 Ross R. The pathogenesis of atherosclerosis:aperspective for the 1990s[J]. Nature, 1993, 362:801-809.10 Ishikawa Y, Asuwa N, Ishii T, et al. Collagenalteration in vascular remodeling by hemodynamicfactors[J]. Virchows Arch, 2000, 437:138-148.11 Ward MR, Tsao PS, Agrotis A, et al. Low bloodf low after angioplasty augments mechanisms ofrestenosis:inward vessel remodeling, cell migration,and activity of genes regulating migration[J].Arterioscler Thromb Vasc Biol, 2001, 21:208-213.12 Steinman DA. Image-based computational f luiddynamics modeling in realistic arterial geometries[J].Ann Biomed Eng, 2002, 30:483-497.13 St einman DA, Thoma s JB, Ladak HM, et al.Reconstruction of carotid bifurcation hemodynamicsand wall thickness using comput ational f luiddynamics and MRI[J]. Magn Reson Med, 2002,47:149-159.14 薛蕴菁, 高培毅, 林燕, 等. 颈动脉分叉血液动力状态的计算流体力学初步研究[J]. 中华放射学杂志, 2006,40:638-641.15 Sui B, Gao P, Lin Y, et al. Blood flow pattern and wallshear stress in the internal carotid artery of healthysubject[J]. Acta Radiologica, 2008, 49:806-814.16 Wu SP, Ri ng g a a r d S, Pe d e r s e n EM. Th r e e -dimensional phase cont rast velocity mappingacquisition improves wall shear stress estimation invivo[J]. Magn Reson Imaging, 2004, 22:345-351.17 Petty W, Brown D, Whisnant P, et al. Ischemic strokesubtypes:a population-based study of functionaloutcome, survival, and recurrence[J]. Stroke, 2000,31:1062-1068.18 Younis HF, Kaazempur-Mofrad MR, Chan RC,et al. Hemody namics and wal l me chanics inhuman carotid bifurcation and its consequencesfor atherogenesis:investigation of inter-individualvariation[J]. Biomech Model Mechanobiol, 2004, 3:17-32.19 Zhou SY, Wang YH, Li YJ, et al. Effect of Shenlianextracts on blood flow and vessel pathological changesin rabbit carotid atherosclerosis model induced by lowshear stress[J]. Zhongguo Zhong Yao Za Zhi, 2013,38:1595-1600.20 Schirmer CM, Malek AM. Computational f luiddynamic characterization of carotid bifurcationstenosis in patient-based geometries[J]. Brain Behav,2012, 2:42-52.21 La Disa JF Jr, Bowers M, Harmann L, et al. Timeefficientpatient-specific quantification of regional carotid artery fluid dynamics and spatial correlationwith plaque burden[J]. Med Phys, 2010, 37:784-792.22 Vozzi F, Bianchi F, Ahluwalia A, et al. Hydrostaticpressure and shear stress affect endothelin-1 and nitricoxide release by endothelial cells in bioreactors[J].Biotechnol J, 2014, 9:146-154.23 Li ZY, Tang T, U-King-Im J, et al. Assessment ofcarotid plaque vulnerability using structural andgeometrical determinants[J]. Circ J, 2008, 72:1092-1099.24 Kock SA, Nygaard JV, Eldrup N, et al. Mechanicalstresses in carotid plaques using MRI-based fluidstructureinteraction models[J]. J Biomech, 2008,41:1651-1658.25 Li ZY, Howarth S, Tang T, et al. Does calciumdeposition play a role in the stability of atheroma?Location may be the key[J]. Cerebrovasc Dis, 2007,24:452-459.26 Groen HC, Gijsen FJ, van der Lugt A, et al. Plaquerupture in the carotid artery is localized at the highshear stress region:a case report[J]. Stroke, 2007,38:2379-2381.27 Trivedi RA, Li ZY, U-King-Im J, et al. Identifyingvulnerable carotid plaques in vivo using highresolution magnetic resonance imaging based finiteelement analysis[J]. J Neurosurg, 2007, 107:536-542.28 Cicha I, Wör ner A, Urschel K, et al. Ca rot idplaque vulnerability:a positive feedback betweenhemodynamic and biochemical mechanisms[J].Stroke, 2011, 42:3502-3510.29 Jing LN, Gao PY, Lin Y, et al. Distribution of wallshear stress in carotid plaques using magneticresonance imaging and computational fluid dynamicsanalysis:a preliminary study[J]. Chin Med J (Engl),2011, 124:1465-1469.30 Tang D, Teng Z, Canton G, et al. Sites of rupture inhuman atherosclerotic carotid plaques are associatedwith high structural stresses:an in vivo MRI-based3D fluid-structure interaction study[J]. Stroke, 2009,40:3258-3263.31 Teng Z, Canton G, Yuan C, et al. 3D critical plaquewall stress is a better predictor of carotid plaquerupture sites than f low shear stress:an in vivoMRI-based 3D FSI study[J]. J Biomech Eng, 2010,132:031007.32 Huang X, Teng Z, Canton G, et al. Intraplaquehemorrhage is associated with higher structuralstresses in human atherosclerotic plaques:an in vivoMRI-based 3D fluid-structure interaction study[J].Biomed Eng Online, 2010, 31:86.33 Teng Z, He J, Degnan AJ, et al. Critical mechanical carotid artery fluid dynamics and spatial correlationwith plaque burden[J]. Med Phys, 2010, 37:784-792.22 Vozzi F, Bianchi F, Ahluwalia A, et al. Hydrostaticpressure and shear stress affect endothelin-1 and nitricoxide release by endothelial cells in bioreactors[J].Biotechnol J, 2014, 9:146-154.23 Li ZY, Tang T, U-King-Im J, et al. Assessment ofcarotid plaque vulnerability using structural andgeometrical determinants[J]. Circ J, 2008, 72:1092-1099.24 Kock SA, Nygaard JV, Eldrup N, et al. Mechanicalstresses in carotid plaques using MRI-based fluidstructureinteraction models[J]. J Biomech, 2008,41:1651-1658.25 Li ZY, Howarth S, Tang T, et al. Does calciumdeposition play a role in the stability of atheroma?Location may be the key[J]. Cerebrovasc Dis, 2007,24:452-459.26 Groen HC, Gijsen FJ, van der Lugt A, et al. Plaquerupture in the carotid artery is localized at the highshear stress region:a case report[J]. Stroke, 2007,38:2379-2381.27 Trivedi RA, Li ZY, U-King-Im J, et al. Identifyingvulnerable carotid plaques in vivo using highresolution magnetic resonance imaging based finiteelement analysis[J]. J Neurosurg, 2007, 107:536-542.28 Cicha I, Wör ner A, Urschel K, et al. Ca rot idplaque vulnerability:a positive feedback betweenhemodynamic and biochemical mechanisms[J].Stroke, 2011, 42:3502-3510.29 Jing LN, Gao PY, Lin Y, et al. Distribution of wallshear stress in carotid plaques using magneticresonance imaging and computational fluid dynamicsanalysis:a preliminary study[J]. Chin Med J (Engl),2011, 124:1465-1469.30 Tang D, Teng Z, Canton G, et al. Sites of rupture inhuman atherosclerotic carotid plaques are associatedwith high structural stresses:an in vivo MRI-based3D fluid-structure interaction study[J]. Stroke, 2009,40:3258-3263.31 Teng Z, Canton G, Yuan C, et al. 3D critical plaquewall stress is a better predictor of carotid plaquerupture sites than f low shear stress:an in vivoMRI-based 3D FSI study[J]. J Biomech Eng, 2010,132:031007.32 Huang X, Teng Z, Canton G, et al. Intraplaquehemorrhage is associated with higher structuralstresses in human atherosclerotic plaques:an in vivoMRI-based 3D fluid-structure interaction study[J].Biomed Eng Online, 2010, 31:86.33 Teng Z, He J, Degnan AJ, et al. Critical mechanical |