急性脑梗死后不宁腿综合征的临床特征

摘要/Abstract

摘要：

目的了解急性脑梗死后不宁腿综合征（restless legs syndrome，RLS）的临床特征，以及其对急性脑梗死预后的影响。方法按照国际不宁腿工作组（International Restless Legs Syndrome Study Group，IRLSSG）定义标准，连续筛查住院治疗的急性脑梗死患者中RLS患者，选择年龄、性别、梗死部位匹配的同时期住院的非RLS脑梗死患者为对照组，比较2组的临床特征及预后。结果研究筛查275例急性脑梗死患者，其中RLS患者19例，患病率为6.91%（19/275）。RLS组年龄（62.89±10.26）岁；非RLS组19例，年龄（62.63±9.96）岁。与对照组比较，RLS组Epworth嗜睡量表（Epworth Sleepiness Scale，ESS）>10分的比例更高（57.9% vs 21.1%，P=0.020），匹兹堡睡眠质量指数（Pittsburgh Sleep Quality Index，PSQI）>15分的比例也更高（47.4% vs 15.8%，P=0.040）。脑梗死后90?d和180?d，RLS组Barthel指数（Barthel Index，BI）低于非RLS组（P值分别是＜0.001和＜0.001），改良Rankin量表（modified Rankin Scale，mRS）评分高于非RLS组（P值分别是0.64和0.04）。RLS组14例（73.68%）患者合并周期性腿动，15例（78.9%）患者合并阻塞性睡眠呼吸障碍。结论急性脑梗死后RLS患者较无RLS患者睡眠质量及预后更差。

文章导读： 本文通过病例对照研究分析急性脑梗死后不宁腿综合征的特征，发现脑梗死后不宁腿综合征患者较无不宁腿综合征患者预后差。

关键词: 急性; 脑梗死; 不宁腿综合征; 预后

Abstract:

Objective To investigate the clinical characteristics and influences of restless legs syndrome (RLS) after acute cerebral infarction. Methods All acute cerebral infarction patients admitted were screened in accordance with the definition criteria of International Restless Legs Syndrome Study Group (IRLSSG). The patients without RLS were matched with a group in similar with age, gender, location of lesion to RLS group. The clinical characteristics of the patients with and without RLS were analyzed. Results Two hundred and seventy-five patients with acute cerebral infarction were studied. Nineteen cases met the diagnostic criteria for RLS. The morbidity rate is 6.91%. The age of RLS group and non-RLS group were (62.89±10.26) vs (62.63±9.96) respectively. The Epworth Sleepiness Scale (ESS) and Pittsburgh Sleep Quality Index (PSQI) of RLS group were higher than non-RLS group. Barthel Index (BI) of RLS group was lower than that in non-RLS group (all P<0.001), the modified Rankin Scale (mRS) score was significantly higher than that in non-RLS group (P=0.64, P=0.04). The prevalence of periodic limb movement and obstructive sleep apnea (OSA) in RLS group were 73.68% and 78.9% respectively. Conclusion The prognosis and sleep quality of patients with RLS after acute cerebral infarction are worse.

Key words: Acute, cerebral infarction; Restless legs syndrome; Outome

丁晓1，邓丽影2. 急性脑梗死后不宁腿综合征的临床特征[J]. 中国卒中杂志, 2015, 10(01): 34-39.

DING Xiao*, DENG Li-Ying. . Clinical Characteristics of Restless Legs Syndrome after Acute Cerebral Infarction[J]. Chinese Journal of Stroke, 2015, 10(01): 34-39.

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