关键词: 脑白质疏松症; 认知障碍; 神经心理学测验

Abstract: Objective To explore mild cognitive impairment with impairment characteristics ofleukoaraiosis(LACI), and to provide the reference for clinical diagnosis and treatment.Methods Seventy-seven patients with LACI and 74 leukoaraiosis(LA) patients without cognitiveimpairment(control group) were tested by Montreal cognitive assessment(MoCA) scale and otherpsychological scales.Results The total score of MoCA(20.84± 3.04) in LACI group was lower than that in the controlgroup(27.38 + 1.25)(P < 0.01).There was significant difference between the two groups in the spaceand execution, depending on-named ability, attention, language ability, abstract ability, delayedmemory ability and directional power of seven cognitive domains(P <0.01). The correlation analysisbetween the total score of the MoCA scores and secondary types showed that except for the namingand language ability, there was a positive correlation between the other five secondary types and thetotal scores, according to high-and-low ranking in the correlation coefficient, which in turn dependson the space and executive function for delay, memory, attention, abstract ability, directional power.Conclusion LACI patients have different damage levels on visual space, execution, named ability,attention, language ability, abstract ability, delayed memory ability, directional power and some othercognitive domains, and visual space and executive function, delayed memory, attention, abstract,directional power ability may be obvious cognitive domains in the earlier damage, the three key linkin the process of memory such as encoding, storage, extraction have existed in the damage.

Key words: Leukoraiosis; Cognition disorders; Neuropsychological tests