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Table of Content

    20 April 2010, Volume 5 Issue 04
    主编手记
    Fear of The Uncertainly
    WANG Yong-Jun
    2010, 5(04):  255-257. 
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    述评
    Optimizing Glycemic Control in Patients with Stroke
    ZHANG Yong-Li;HE Mao-Lin
    2010, 5(04):  258-261. 
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    会议报道
    Highlight Report of International Stroke Conference 2010
    ZHAO Xing-Quan
    2010, 5(04):  262-265. 
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    论著
    Insulin Resistance among Nondiabetic Patients with Acute Ischemic Stroke and the Triglycerides-High Density Lipoprotein-Cholesterol Ratio
    ZHENG Hua-Guang;JIA Qian;QI Dong;et al.
    2010, 5(04):  266-276. 
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    Objective The purpose of this study was to determine the prevalence of insulin resistanceamong nondiabetic patients with acute ischemic stroke and to assess the association between thetriglycerides-HDL-cholesterol ratio (TG:HDL-C) and impaired insulin sensitivity.Methods From August 2008 to December 2009, We enrolled 610 unselected subjects who wereadmitted to the neurological department in TianTan Hospital in this study prospectively. Eligiblesubjects without medical history of diabetes underwent an oral glucose tolerance test (OGTT) 14±3 days after their event. The homeostatic model assessment (HOMA) was used to estimate insulinresistance (HOMA-IR). Risk factors correlated with insulin resistance included blood pressure,body mass index(BMI), HDL cholesterol, triglycerides, triglycerides-HDL-cholesterol ratio (TG:HDL-C), high-sensitivity C-reactive protein (hsCRP), fibrinogen and hyperhomocysteinemia etc.Results In 375 out of 480 ischemic stroke patients without previous DM, glucometabolic statewas determined by oral glucose tolerance test (OGTT). A normal glucose tolerance (NGT) wasidentified in 123 patients, isolated-impaired glucose regulation (I-IFG) in 5 patients, isolatedimpairedglucose tolerance(I-IGT) in 108 patients, combined glucose intolerance (CGI) in 10patients.The propotion of insulin resistance was 8.1% in the NGT group, as compared with 20.0%,17.6%, 30.0% in the I-IFG group, I-IGT group and CGI group respectively (χ2 for trends, P <0.01).TG:HDL-C and hsCRP was associated with an increased risk of impaired insulin sensitivityindependently. The adjusted odds ratio of having insulin resistance was 6.09 [95% confidenceinterval (CI ) 1.43-25.87, P <0.05] for the top TG/HDL level quater and 4.11(95%CI 1.06-15.95,P <0.05) for middle quarters combined than for the bottom quater. The adjusted odds ratio of havinginsulin resistance was 1.19 (95%CI 0.38-3.74, P >0.05) for the top sCRP level quater and 3.98(95%CI1.14-13.89, P <0.05) for middle quarters combined than for the bottom quater.Conclusion Our data revealed that HOMA-estimated insulin resistance and subclinicalinflammation are present in nondiabetic patients with acute ischemic stroke. The TG:HDL-C was apredictor for impaired insulin sensitivity. These findings have important implications for diagnosisand therapy in case that treatment to improve insulin sensitivity is shown to reduce risk forsubsequent stroke and heart disease.
    Investigations of Glucose Metabolism Disorders in Patients with Transient Ischemic Attack
    ZENG Guang-Lun;ZHANG Cheng-Guo;HUANG Shu-Yun;et al.
    2010, 5(04):  277-280. 
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    Objective To investigate the glucose metabolism of inpatients with transient ischemic attack (TIA).Methods One hundred and twenty-nine inpatients with TIA from July 2007 to March 2009 werecollected. We recorded the clinical features and biochemical indices of all patients. Head computedtomography (CT) or magnetic resonance imaging (MRI) was performed.Results In all patients, 72 cases (55.8%) had abnormal blood glucose, including 35 cases (27.1%)of diabetes and 37 cases (28.7%) impaired glucose tolerance; 57 cases (44.2%) were normalglucose tolerance. Fifty eight cases were anterior circulation patients, 31 cases were abnormalblood glucose (53.4%); 71 cases were posterior circulation patients, 41 cases were abnormal bloodglucose (57.7%).The abnormal blood glucose frequency between anterior circulation and posteriorcirculation do not have statistical significance.Conclusion Most of TIA patients have impaired glucose regulation. In the frequency, anterior andposterior circulation patients with abnormal glucose metabolism do not have statistical significance.Oral glucose tolerance test (OGTT) can more accurately detect abnormal glucose metabolismpatients.
    Relationship between Glycometabolism Abnormality and Leukoaraiosis
    QI Dong;WANG Chun-Xue;JIA Qian;et al.
    2010, 5(04):  281-281285. 
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    Objective To explorer the effects of hyperglycemia on leukoaraiosis.Methods We recruited 196 patients with leukoaraiosis (LA) and non-leukoaraiosis (non-LA)who were hospitalized in neurology department of Beijing Tiantan hospital between January 2007to September 2009, the number of cases in each group were 98. Fasting plasma glucose (FPG),glucose tolerance test (OGTT), age, gender, blood pressure, blood fat, plasma homocysteine level(HbA1c), high sensitivity C-reactive protein (hs-CRP) and plasma homocysteic acid (pHCY) weretested after rolled in. The informations were compared and analyzed in different groups.Results The simple factor analysis showed that the rate of patients with hyperglycemia and thelevel of glucose in LA group were significant higher than non-LA group and the data showed astatistical significance (P <0.05). There was a significantly correlated between glycometabolismabnormality and the severity of leukoaraiosis (P =0.011). Variable in logistic regression showed themore important risk factors were age, hypertension and the level of pHCY (OR =1.108, 2.574, 1.071).Conclusion The study proves that there is significantly correlation between hyperglycemia andleukoaraiosis. In the patients,the more severe of glycometabolism abnormality,the higher severity ofLA can be detected.Age, hypertension, and the level of pHCY can be considered as risk factors forleukoaraiosis.
    Effects Of Directional PLGA Scaffolds Transplantation On Hind Limbs Motor Function And Motor Evoked Potentials In Rats With Hemisected Spinal Cord Injury
    ZHANG Shao-Dong;HAO Shu-Yu;LI Jun-Hua;et al.
    2010, 5(04):  286-290. 
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    Objective To assess the effects of directional poly-lactic-co-glycolicacid (PLGA) scaffoldstransplantation on hind limbs motor function after hemisected spinal cord injury (hSCI) in rats.Methods Female adult wistar rats were randomly divided into four groups: normal group (n=15);sham operation group (n=15); hSCI group (n=18) and PLGA group (n=15). The spinal cord washemisected in the rats of hSCI group. In PLGA group, the rats suffer the spianal cord hemisectedinjury and the directional PLGA scaffold was transplanted into the injury site. Inclined plane(IP)test, the Basso Beattie Bresnahan locomotor rating scale (BBB) score and motor evoked potentials(MEP) were adopted to assess hind limbs motor functional revival in 12 weeks after operation. Thestatistical data were tested by One-Way ANOVA analysis and LSD test.Results The inclined plane angle in PLGA group at 4 and 8 weeks after operation was higher thanthat in group hSCI: 4w (56.0±2.0) and (54.7±2.3), P =0.030; 8w (64.7±2.4) and (62.3±2.3), P =0.038;the BBB score in PLGA group is higher than that in hSCI at 4 weeks: (7.9±1.2) and (7.1±1.3),P =0.042; the motor evoked potential amplitude in PLGA group were significant difference than thatin group hCSI at 12 weeks: (29.9±11.0μV) and (21.4±10.4μV), P =0.039.Conclusion The directional PLGA scaffolds transplantation may improve the hind limbs motorfunction and the recovery of MEPs in rats with hSCI.
    Evaluation of the Predominant Role in Patients with Spastic Equinus Foot after Stroke: A Clinical Study of the Effects of Block of Motor Nerve Branches to the Triceps Surae Muscle
    LIU Zhi-Hua;ZHANG Hong-Cui;YU Da-Jun;et al.
    2010, 5(04):  291-298. 
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    Objective To evaluate the prominent role of the triceps surae muscle through selective anestheticblocks of motor nerve branches to the triceps surae muscle on lower limb in patients with spasticequinus foot.Methods Thirty patients with stroke were assessed before and after selective anesthetic blockof the superior soleus nerve or the gastrocnemius nerve, which performed by lidocaine injection.Clinical assessments such as SR(stretch reflex), Ashworth scale, rROM(rest range of motion),AROM(active range of motion), PROM(passive range of motion), strength of plantarflexion muscle,walking speed for 10m(at cosy speed and volant speed, separately), cadence, walking distance for3mins, PCI(physical consume index), step length, toe out angle were performed 30mins beforeand after each motor block. The patients were devided into three groups, they were preoperativepostgastrocnemius,preoperative- postsoleus, postgastrocnemius – postsoleus separately. Wecompared differences in these indicators.Results Spasm index such as stretch reflex, Ashworth scale, AROM and PROM were all decreasedin postgastrocnemius, there were statistically differences compared with preoperative, (P all <0.01).Stretch reflex, Ashworth scale, rROM, AROM and PROM were all decreased in postsoleus, (P all<0.01); there were significant differences between two blocks in each of them, they showed thaton SR, AROM and PROM P all <0.01, on Ashworth, rROM P all <0.05; Plantar flexor musclestrength decreased in postgastrocnemius(P <0.01) but not in postsoleus, comparison of two blocksP <0.01; there were no significant differences on walking targets in postgastrocnemius but therewere statistically differences in postsoleus except for walking distance for 3mins compared withpreoperative, on walking speed for 10m at volant speed and cadence P all<0.01, on walking speedfor 10m at cosy speed and PCI P all<0.05.Also there were significant difference between the twoblocks except for walking distance for 3mins, they showed that on walking speed for 10m at cosyspeed P <0.05, other index P all<0.01.There were no significant difference for step length andtoe out angle in the affected side compared with preoperative, also no statistically difference wasobserved between the two blocks in the affected side.Conclusion Both soleus nerve block and gastrocnemius nerve block could alleviate spasticityin patients with spastic equinus foot, but soleus nerve block appeared more appropriate thangastrocnemius nerve block to relieve spasticity clinically, which mainly manifested in people'swalking ability. It constitutes an additional argument in favor of the predominant role of the soleusin spastic foot.
    Application of Urinary Kallikrein in Patients with Acute Cerebral Infarction
    MAO Shi-Xian;CHU Lan;XU Zhu;et al.
    2010, 5(04):  303-306. 
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    Objective To investigate the efficacy of Urinary Kallikrein in patients with acute cerebralinfarction (ACI).Methods Sixty-two ACI patients were randomly divided into the control group and the UrinaryKallikrein group. Both groups of patients were received conventional therapy, such as anti-plateletaggregation and control of blood pressure. Besides the conventional therapy, The patients in theUrinary Kallikrein group also received Urinary Kallikrein treatment for 14 days. The patients wereevaluated by the neurologic function score, therapeutic efficiency and biochemical indicator beforeand after 14 days therapy.Results The neurologic functional recovery of the Urinary Kallikrein group obviously surpassedthan that of the control group. There was significantly different between the two groups after14 days therapy in the neurologic function score and the total efficiency (P =0.025 and P =0.021respectively). In the Urinary Kallikrein group, there was not significantly different between beforeand after 14 days therapy in biochemical indicator (P >0.05).Conclusion Urinary Kallikrein treatment on acute cerebral infarction was effective.
    专题论坛
    Glucose Metabolism Disorders and Stroke
    HE Mao-Lin
    2010, 5(04):  308-308. 
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    The Clinical Trials of Hyperglycemic Control in Prevention and Early Management for Stroke
    TANG Jing-Jing;YANG Wan-Yong;XU An-Ding;et al
    2010, 5(04):  315-318. 
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    Postprandial Hyperglycemia and Stroke
    ZHANG Guo-Hua;ZHANG Cheng-Guo
    2010, 5(04):  319-323. 
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    病例讨论
    One Case of Pseudotumor-like Intracerebral Hematoma Caused by Distal Anterior Cerebral Artery Aneurysm
    WANG Xin-Gao;ZHANG Yu-Mei;YANG Zhong-Hua;et al
    2010, 5(04):  324-327. 
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    指南与规范
    Alberta Provincial Stroke Strategy_Emergency Management of Acute Stroke(Excerpt)
    MA Chun;WANG Chun-Yu
    2010, 5(04):  328-331. 
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    综述
    From Pre-diabetes to Increased Risk for Diabetes-Advance in the Association between Impaired Glucose Regulation and Stroke
    ZHENG Hua-Guang;JIA Qian;WANG Chun-Xue;et al.
    2010, 5(04):  332-337. 
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    Prospective epidemiological study indicated recently that diabetes has become amajor public health problem in China because of the rapid changes in lifestyle. The presence ofdiabetes increases the risk of stroke 2- to 5-fold. Not only patients with diabetes are at increased riskof stroke but also patients with impaired fasting glucose (IFG) and impaired glucose tolerance (IGT).Underlying pathogenetic mechanisms include insulin resistance, dyslipidemia, procoagulability,impaired fibrinolysis,chronic inflammation and endothelial dysfunction. Pre-diabetes (orintermediate hyperglycaemia) has been renamed “Categories of increased risk for diabetes” in theAmerican Diabetes Association (ADA) Guideline 2010 and A1c range of 5.7–6.4% included asa category of increased risk for future diabetes.Randomized controlled trials(RCTs) have shownthat individuals at high risk for developing diabetes (those with IFG, IGT, or both) can be giveninterventions that significantly decrease the rate of onset of diabetes.Previous study suggested thattreating IGT patients is associated with a significant reduction in the risk of cardiovascular diseaseand hypertension,which need further evaluation.Strategies aimed at screening and treating strokepatients with increased risk for diabetes are needed.
    Cerebral Hyperperfusion Syndrome after Carotid Endarterectomy
    CHEN Yu;WU Wei-Wei;LIU Bao;et al.
    2010, 5(04):  338-342. 
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    Cerebral hyperperfusion syndrome (CHS) after carotid endarterectomy is arare, serious complication of carotid endarterectomy. If not treated properly, hyperperfusionsyndrome can result in severe brain edema, cerebral haemorrhage or even death. This review willoutline the current knowledge of CHS, including the definition, pathophysiological basis, riskfactors, examinations and therapies. It will help clinical doctors to prevent this potentially severecomplication.
    教学园地
    Emphasis on Teaching Methods to Improve Effectiveness of Clinical Practice in Neurology
    ZHANG Yu-Mei;LAI Zong-Li;SUN Hai-Xin;et al
    2010, 5(04):  343-346. 
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