多模态磁共振成像评估颈动脉粥样硬化易损斑块的应用进展

doi:10.3969/j.issn.1673-5765.2025.10.014

摘要/Abstract

摘要： 颈动脉粥样硬化（carotid atherosclerosis，CAS）易损斑块是缺血性卒中的主要病因之一，其破裂与脱落在缺血性卒中的发生与发展中起着至关重要的作用。早期识别颈动脉狭窄程度和易损斑块成分特征，进行针对性防治，可改善患者预后。多模态MRI不仅能清晰显示CAS易损斑块的形态与大小，还可借助多参数成像技术评估斑块成分、炎症反应及血流动力学参数等，从而实现对斑块的全面评估。本综述通过回顾多模态MRI在CAS易损斑块评估中的应用进展，分析斑块特征对缺血性卒中的影响，探讨该技术在CAS易损斑块成像中存在的问题，并对其未来研究方向进行展望。

文章导读： 本文探讨了多模态MRI在颈动脉粥样硬化易损斑块评估中的应用进展，为缺血性卒中的早期诊断提供重要依据。

关键词: 斑块; 动脉粥样硬化; 多模态磁共振成像

Abstract: Carotid atherosclerotic vulnerable plaques are one of the major etiologies of ischemic stroke. Their rupture and detachment play a crucial role in the development and progression of ischemic stroke. Early identification of the degree of carotid artery stenosis and compositional characteristics of vulnerable plaques can improve patient prognosis. Multimodal MRI can not only clearly depict the morphology and size of carotid atherosclerotic vulnerable plaques but also utilize multi-parametric imaging techniques to assess plaque composition, inflammatory response, and hemodynamic parameters, thereby enabling a comprehensive assessment of the plaques. This review summarizes the application progress of multimodal MRI in the assessment of carotid atherosclerotic vulnerable plaques, analyzes the effect of plaque characteristics on ischemic stroke, discusses current challenges in plaque imaging, and provides an outlook on its future research directions.

Key words: Plaque; Atherosclerosis; Multimodal magnetic resonance imaging

中图分类号:

廖明莎, 陈澜菁, 苟玉林, 曾妮, 傅建梅, 戴贵东. 多模态磁共振成像评估颈动脉粥样硬化易损斑块的应用进展[J]. 中国卒中杂志, 2025, 20(10): 1318-1328.

LIAO Mingsha, CHEN Lanjing, GOU Yulin, ZENG Ni, FU Jianmei, DAI Guidong. Research Progress on the Application of Multimodal Magnetic Resonance Imaging in the Assessment of Carotid Atherosclerotic Vulnerable Plaques[J]. Chinese Journal of Stroke, 2025, 20(10): 1318-1328.

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