1 Venkatasubramanian C, Mlynash M, Finley-CaulfieldA, et al. Natural history of perihematomal edema afterintracerebral hemorrhage measured by serial magneticresonance imaging[J]. Stroke, 2011, 42:73-80.2 Hill J, Rom S, Ramirez SH, et al. Emerging roles ofpericytes in the regulation of the neurovascular unitin health and disease[J]. J Neuroimmune Pharmacol,2014, 9:591-605.3 Willis CL. Imaging in vivo astrocyte/endothelial cellinteractions at the blood-brain barrier[J]. MethodsMol Biol, 2012, 814:515-529.4 Keep RF, Xi G, Hua Y, et al. Clot formation, vascularrepai r and hematoma resolut ion af ter ICH, acoordinating role for thrombin?[J]. Acta NeurochirSuppl, 2011, 111:71-75.5 Babu R, Bagley JH, Di C, et al. Thrombin and heminas central factors in the mechanisms of intracerebralhemorrhage-induced secondary brain injury and aspotential targets for intervention[J]. Neurosurg Focus,2012, 32:E8.6 Liu DZ, Ander BP, Xu H, et al. Blood brain barrierbreakdown and repair by src after thrombin-inducedinjury[J]. Ann Neurol, 2010, 67:526-533.7 Liu DZ, Sharp FR. The dual role of SRC kinases inintracerebral hemorrhage[J]. Acta Neurochir Suppl,2011, 111:77-81.8 Liu DZ, Sharp FR. Excitatory and mitogenic signalingin cell death, blood-brain barrier breakdown, and BBBrepair after intracerebral hemorrhage[J]. Transl StrokeRes, 2012, 3:62-69.9 Ma Q, Huang B, Khatibi N, et al. PDGFR-α inhibitionpreserves blood-brain barrier after intracerebralhemorrhage[J]. Ann Neurol, 2011, 70:920-931.10 Cui GY, Gao XM, Qi SH, et al. The action of thrombinin intracerebral hemorrhage induced brain damageis mediated via PKCα/PKCδ signaling[J]. Brain Res,2011, 1398:86-93.11 Wang J. Pre cl inical and cl inical resea rch oninflammation after intracerebral hemorrhage[J]. ProgNeurobiol, 2010, 92:463-477.12 Wang J, Doré S. Inf lammation after intracerebralhemorrhage[J]. J Cereb Blood Flow Metab, 2007,27:894-908.13 Bijli KM, Minhajuddin M, Fazal F, et al. c-Srcinteracts with and phosphorylates RelA/p65 topromote thrombin-induced ICAM-1 expression inendothelial cells[J]. Am J Physiol Lung Cell MolPhysiol, 2007, 292:L396-L404.14 Moxon-Emre I, Schlichter LC. Neutrophil depletionreduces blood-brain barrier breakdown, axon injury,and inflammation after intracerebral hemorrhage[J]. JNeuropathol Exp Neurol, 2011, 70:218-235.15 Rosell A, Cuadrado E, Ortega-Aznar A, et al. MMP-9-positive neutrophil infiltration is associated toblood-brain barrier breakdown and basal laminatype IV collagen degradation during hemorrhagictransformation after human ischemic stroke[J]. Stroke,2008, 39:1121-1126.16 Lischper M, Beuck S, Thanabalasundaram G, et al.Metalloproteinase mediated occludin cleavage in thecerebral microcapillary endothelium under pathologicalconditions[J]. Brain Res, 2010, 1326:114-127.17 Liu J, Jin X, Liu KJ, et al. Matrix metalloproteinase-2-mediated occluding degradation and caveolin-1-mediated claudin-5 redistribution contribute to bloodbrainbarrier damage in early ischemic stroke stage[J].J Neurosci, 2012, 32:3044-3057.18 Florczak-Rzepka M, Grond-Ginsbach C, MontanerJ, et al. Mat r ix met alloproteina ses in humanspontaneous intracerebral hemorrhage:an update[J].Cerebrovasc Dis, 2012, 34:249-262.19 Chang JJ, Emanuel BA, Mack WJ, et al. Matrixmetalloproteinase-9:Dual role and temporal profilein intracerebral hemorrhage[J]. J Stroke CerebrovascDis, 2014, 23:2498-2505.20 Seo JH, Guo S, Lok J, et al. Neurovascular matrixmetalloproteinases and the blood-brain barrier[J].Curr Pharm Des, 2012, 18:3645-3648.21 Lei C, Lin S, Zhang C, et al. Activation of cerebralrecover y by mat r ix met alloproteinase -9 af terintracerebral hemorrhage[J]. Neuroscience, 2013,230:86-93.22 Ducruet AF, Zacharia BE, Hickman ZL, et al. Thecomplement cascade as a therapeutic target inintracerebral hemorrhage[J]. Exp Neurol, 2009,219:398-403.23 Garrett MC, Otten ML, Starke RM, et al. Synergisticneuroprotective effects of C3a and C5a receptorblockade following intracerebral hemorrhage[J]. BrainRes, 2009, 1298:171-177.24 Li G, Fan RM, Chen JL, et al. Neuroprotective effectsof argatroban and C5a receptor antagonist (PMX53)following intracerebral haemorrhage[J]. Clin ExpImmunol, 2014, 175:285-295. 25 Hua Y, Xi G, Keep RF, et al. Complement activationin the br ain af ter exper iment al int r acerebr alhemorrhage[J]. J Neurosurg, 2000, 92:1016-1022.26 Xi G, Keep RF, Hoff JT. Erythrocytes and delayedbrain edema formation following intracerebralhemorrhage in rats[J]. J Neurosurg, 1998, 89:991-996.27 Lin S, Yin Q, Zhong Q, et al. Heme activates TLR4-mediated inf lammatory injury via MyD88/TRIFsignaling pathway in intracerebral hemorrhage[J].Neuroinflammation, 2012, 9:46.28 Katsu M, Niizuma K, Yoshioka H, et al. Hemoglobininducedoxidative st ress cont ributes to mat rixmetalloproteinase activation and blood-brain barrierdysfunction in vivo[J]. J Cereb Blood Flow Metab,2010, 30:1939-19350.29 Yang S, Chen Y, Deng X, et al. Hemoglobin-inducednitric oxide synthase overexpression and nitric oxideproduction contribute to blood-brain barrier disruptionin the rat[J]. J Mol Neurosci, 2013, 51:352-363.30 Di ng R, Chen Y, Yang S, et a l. Blood-br a i nba r r ier disr upt ion induced by hemoglobin invivo:Involvement of up-regulation of nitric oxidesynthase and peroxynitrite formation[J]. Brain Res,2014, 1571:25-38.31 Tsou HK, Su CM, Chen HT, et al. Integrin-linkedkinase is involved in TNF-alpha-induced induciblenitric-oxide synthase expression in myoblasts[J]. JCell Biochem, 2010, 109:1244-1253.32 鲍旭辉, 黄峰平. 铁在脑出血后脑水肿形成中的机制研究进展[J]. 中国神经精神疾病杂志, 2007, 33:507-510.33 Qing WG, Dong YQ, Ping TQ, et al. Brain edemaafter intracerebral hemorrhage in rats:the role ofiron overload and aquaporin 4[J]. J Neurosurg, 2009,110:462-468.34 Sun Z, Zhao Z, Zhao S, et al. Recombinant hirudintreatment modulates aquaporin-4 and aquaporin-9expression after intracerebral hemorrhage in vivo[J].Mol Biol Rep, 2009, 36:1119-1127.35 Manaenko A, Fathali N, Khatibi NH, et al. ArgininevasopressinV1a receptor inhibition improvesneurologic outcomes following an intracerebralhemorrhagic brain injury[J]. Neurochem Int, 2011,58:542-548.36 Tang Y, Wu P, Su J, et al. Effects of Aquaporin-4on edema format ion fol lowi ng i nt r a c e r ebr a lhemorrhage[J]. Exp Neurol, 2010, 223:485-495.37 Chu H, Tang Y, Dong Q. Protection of vascularendothelial growth factor to brain edema followingi nt r a c e r e b r a l h emo r r h a ge a n d i t s i nvolve dmechanisms:effect of Aquaporin-4[J]. PLoS One,2013, 8:e66051.38 Chu H, Tang Y, Dong Q. Protection of granulocytecolonystimulating factor to hemorrhagic braininjuries and its involved mechanisms:effects ofvascular endothelial growth factor and aquaporin-4[J].Neuroscience, 2014, 260:59-72.39 Chu H, Ding H, Tang Y, et al. Erythropoietin protectsagainst hemorrhagic blood-brain barrier disruptionthrough the effects of aquaporin-4[J]. Lab Invest,2014, 94:1042-1053.40 Papadopoulos MC, Saadoun S, Binder DK, et al.Molecular mechanisms of brain tumor edema[J].Neuroscience, 2004, 129:1011-1020.41 Thrane AS, Rappold PM, Fujita T, et al. Critical roleof aquaporin-4 (AQP4) in astrocytic Ca2+ signalingevents elicited by cerebral edema[J]. Proc Natl AcadSci U S A, 2011, 108:846-851. |