关键词: 皮质下缺血性血管病; 认知障碍; 抑郁; 心理学; 医学

Abstract: Objective To investigate cognitive and emotional charcteristics of subcortical ischemic vascular disease (SIVD).Methods Detailed clinical interviews, neuropsychological and psychiatric assessments were administrated on ischemic stroke patients who fulfilled the criteria of SIVD.Results Mean age of 50 patients was 70.3±7.7 years old, 78% were male, 20 patients(40%) were with mild SIVD while the rest 30 were with moderate to severe SIVD. Among 33 patients whom were diagnosed as vascular cognitive impairment(VCI), 24(72.7%) were diagnosed as vascular cognitive impairment no dementia(V-CIND), 11(33.3%)were with single cognitive domain deficit,and 22(66.7%)were with multi-domain deficits. Executive function and memory were the most prominently impaired domains. Neither language nor spatial function was impaired separately among them. 13 VCI patients were depressed(39.3%) while 2 out of 17 SIVD patients with normal cognition were depressed(P =0.043). Delusions, hallucination, elation/euphoria and nighttime behavior disorders were only seen in vascular dementia patients. The proportion of cognitive impairment was significantly higher in patients with moderate to severe SIVD than those with mild SIVD(P =0.002).There was a tendency for more depression among patients with moderate to severe SIVD than those with mild SIVD(P =0.059).Conclusion Cognitive impairments, especially the V-CIND, were common in SIVD patients. Executive function and memory were the most vulnerable cognitive domains. Cognition impairment paralleled with depression among SIVD patients indicates that frontal cortical-subcortical circuitinjury might be the mechanism underneath.

Key words: Subcortical ischemic vascular disease; Cognition disorders; Depression; Psychology; medical