关键词: 谷氨酸; 抑郁; 卒中后; 受体; 谷氨酸

Abstract: Post-stroke depression (PSD) is one of the most common complications aftercerebral vascular disease, which can have a severe influence on the life of the patients, prolongsthe rehabilitation time, increases the rate of disability and fatality, and increases the load of bothpatients and their relatives. Its pathogenesis isn’t known completely. The main treatment of PSDis antidepressive drug. Drugs increasing the synaptic availability of serotonin and norepinephrinehave been used to treat depression for many years in clinical. However, significant symptomimprovement requires 2-4 weeks of treatment and a first course of therapy provides symptomrelief to only 60%-65% of patients. The increasing understanding of the molecular mechanismsof depression shows that glutamate and its receptors are also involved in depression .Here wedescribes the relationship of glutamate and its receptors between PSD.

Key words: Glutamic acid; Depression; post-stroke; Receptors; glutamate