关键词: 颅内出血; 高血压性; 抑郁; 卒中后; 体层摄影术; X线计算机

Abstract: Objective To investigate the determinants of poststroke depression (PSD) in patients withhypertensive intracerebral hemorrhage (ICH).Methods Sixty-five patients suffered from acute hypertensive intracerebral hemorrhage withrelated clinical materials such as gender, age, neurological deficit severity scale ( NIHSS) aswell as the brain computer tomography(CT) findings were screened prospectively. All patientswere evaluated at day 14 and 3 months after ICH onset for poststroke depression and quality oflife with the Hamilton Depression Rating Scale (HDRS) and the modified Rankin Scale (mRS),respectively. Univariate analysis and multivariate stepwise logistic regression were used toanalyze the relationships between clinical materials and CT features and PSD.Results Fifty-seven of sixty-five patients completed the assessment at day 14 and 53 patientscompleted the follow-up at 3 months. About thirty-five percent and thirty-eight percentrespectively reported the HDRS score greater than 7 at day 14 and 3 months after ICH onset,indicating at least a minor degree of poststroke depression. Univariate analysis showed thatthere was a relationship between first NIHSS score and PSD at day 14 after ICH onset (P =0.027).Gender, hemorrhage location and ICH volume were correlated with PSD at 3 months after ICHonset. Compared with the non-PSD, male patients in the PSD group were less (P =0.038) and theproportion of hemorrhage located in basal ganglia was greater (P =0.031) as well as the averageof ICH volume was larger (P =0.046). Multivariate analysis demonstrated that ICH volume was apredictor of PSD at 3 months after ICH onset (P =0.049).Conclusion NIHSS score and CT features may be used to assess poststroke depression inpatients with intracrebral hemorrhage, CT characteristics together with neurological deficit severity scale can provide objective evidence for comprehensive treatment of hypertensiveintracerebral hemorrhage.

Key words: Intracerebral hemorrhage; hypertensive; Depression; poststroke; Tomography; X-ray computed