›› 2012, Vol. 7 ›› Issue (09): 742-746.

• 综述 • 上一篇    下一篇

脑小血管病变和抑郁的关系

胡蓉,杨淞然,潘小平   

  1. 广州医学院附属广州市第一人民医院神经科
  • 收稿日期:2012-04-12 修回日期:2012-03-12 出版日期:2012-09-20 发布日期:2012-09-20
  • 通讯作者: 潘小平

Relationship between Cerebral Small Vessel Disease and Depression

HU Rong, YANG Song-Ran, PAN Xiao-Ping   

  • Received:2012-04-12 Revised:2012-03-12 Online:2012-09-20 Published:2012-09-20
  • Contact: PAN Xiao-Ping

摘要: 脑小血管病变是指一组累及脑部小动脉、细动脉和静脉以及毛细血管病变的总称,影像学特点主要包括脑白质病变、腔隙性脑梗死和微出血。脑小血管病变与抑郁的发病及预后相关,其主要的作用机制为小血管病变破坏了皮质-纹状体-苍白球-丘脑皮质环路。本文针对脑小血管病变与抑郁的关系这一热点问题,分别从脑白质病变、腔隙性脑梗死及微出血与抑郁的关系方面对其进行阐述。

关键词: 脑小血管病变; 抑郁; 脑白质病变; 腔隙性脑梗死; 微出血

Abstract: The term cerebral small vessel disease refers to a group of pathological processes withvarious aetiologies that affect the small arteries, arterioles, venules, and capillaries of the brain. Thecerebral small vessel disease in imaging are mainly include white matter lesions, lacunar infarctsand microbleeds. It's related to the incidence and prognosis of depression, the main mechanism isthat small vascular lesions destroy the cortico-striato-pallido-thalamo-cortical(CSPTC) systems.This review aims to summarize the relations between the cerebral small vessel disease anddepression respectively from the white matter lesions, brain of lacunar infarcts and microbleeds.

Key words: cerebral small vessel disease; depression; white matter lesions; lacunar infarcts; microbleeds