关键词: 分支动脉粥样硬化病; 腔隙性脑梗死; 临床特征; meta分析

Abstract:

Objective To make a further comparison for the clinical differences between branch atheromatous disease(BAD) and lacunar infarction(LI). Methods We searched the Chinese and foreign language databases for relevant studies. Statistical analysis were performed by RevMan 5.2 software. Results In China, BAD patients were younger than LI patients(MD -2.70, 95%CI -4.29~-1.11, P <0.01); In Japan, BAD patients were older than LI patients(MD 2.58, 95%CI 0.75~4.41, P <0.01). Hyperlipidaemia affected more BAD patients(OR 1.26, 95%CI 1.03~1.55, P =0.03). After the sensitivity analysis, diabetes mellitus(OR 1.28, 95%CI 1.02~1.61, P =0.03), initial national institutes of health stroke scale(NIHSS score)(MD 0.76, 95%CI 0.50~1.02, P <0.01) and prognosis (OR 0.54, 95%CI 0.38~0.77, P <0.01) showed significant differences between BAD and LI. Conclusion Hyperlipidaemia and diabetes mellitus affected more BAD patients, compared to LI patients. The nerve functional and prognosis of BAD patients were worse than LI patients. The characteristic of age distribution in Chinese BAD and LI patients was contrary to Japanese.

Key words: Branch atheromatous disease; Lacunar infarction; Clinical characteristics; Metaanalysis