关键词: 支架; 血管成形术; 肝素

Abstract: Objective To access the safety of low-dose heparin in comparison to a high-dose regimen inpatients undergoing intracranial stent-assisted angioplasty.Methods We performed a prospective random, double-blind, comparative study from Oct2004 to Mar 2006. The patients undergoing intracranial stent-assisted angioplasty in our centerwere randomly assigned to receive low dose of heparin (2000 IU plus 500 IU/h) or high doseof heparin (3000 IU plus 800 IU/h) during the procedure. The groups were compared for thefollowing primary endpoints until hospital discharge: target lesion acute thrombosis, intracranialhemorrhage (ICH) and death. The activated clotting time (ACT) was measured.Results The overall angioplasty success rate was 93% (65/70 lesions). Stents were placed in94.7% (36/38) and 90.6% (29/32) of patients in the low-dose and high-dose groups, respectively(P =0.65). The low dose of heparin group did not increase target-lesion thrombosis (3.0% vs 3.2%,P =1.00) and had a low risk of intracranial hemorrhage (3.0% vs 12.9%, P =0.19). However, thisdifference was not statistically significant.Conclusion The use of a low-dose heparin regimen did not increase the incidence of target lesionthrombosis. Intraoperative low-dose heparin seems to be safe for patients undergoing intracranialstent-assisted angioplasty, but these data should be confirmed in a larger trial.

Key words: Stents; Angioplasty; Heparin