甘油三酯-葡萄糖指数在烟雾病患者中的特征分析：1项病例对照研究

doi:10.3969/j.issn.1673-5765.2025.10.009

中国卒中杂志 ›› 2025, Vol. 20 ›› Issue (10): 1270-1276.DOI: 10.3969/j.issn.1673-5765.2025.10.009

甘油三酯-葡萄糖指数在烟雾病患者中的特征分析：1项病例对照研究

孙旭东，曾超凡，陈颢元，李昊，张岩，张谦

北京 100070 首都医科大学附属北京天坛医院神经外科学中心，国家神经系统疾病临床医学研究中心

收稿日期:2025-02-05 修回日期:2025-09-08 接受日期:2025-09-15 出版日期:2025-10-20 发布日期:2025-10-20
通讯作者: 张谦 zhangqianttchina@163.com
基金资助:
北京市属医院科研培育计划（PX2024022）

Analysis of Triglyceride-Glucose Index Characteristics in Patients with Moyamoya Disease: A Case-Control Study

SUN Xudong, ZENG Chaofan, CHEN Haoyuan, LI Hao, ZHANG Yan, ZHANG Qian

Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, China National Clinical Research Center for Neurological Diseases, Beijing 100070, China

Received:2025-02-05 Revised:2025-09-08 Accepted:2025-09-15 Online:2025-10-20 Published:2025-10-20
Contact: ZHANG Qian, E-mail: zhangqianttchina@163.com

摘要/Abstract

摘要： 目的探讨甘油三酯-葡萄糖（triglyceride-glucose，TyG）指数与烟雾病及其临床表现的关系。
方法回顾性连续纳入2022年8月—2024年5月于首都医科大学附属北京天坛医院神经外科住院治疗的烟雾病患者及同时期健康对照者，并对其进行性别和年龄倾向性评分匹配，将匹配后的烟雾病患者纳入烟雾病组，健康对照者纳入对照组。收集烟雾病患者入院时人口学资料、实验室检查结果及影像学检查资料，并计算TyG指数。采用logistic回归分析，探讨TyG指数与烟雾病Suzuki分期及临床表现的关系。
结果共纳入205例烟雾病患者及231例健康对照者，经倾向性评分匹配后，最终匹配到烟雾病组与对照组各187例。烟雾病组TyG指数高于对照组[8.54（8.12～8.95）vs. 8.05（7.81～8.42），P<0.001]。烟雾病组内不同Suzuki分期及临床表现之间的TyG指数差异不具有统计学意义。相关性分析显示，烟雾病组（r=0.31，P<0.001）与对照组（r=0.28，P<0.001）的TyG指数均与年龄增加呈正相关，且在相同年龄段中，烟雾病组的TyG指数高于对照组。logistic回归分析提示，TyG指数升高与Suzuki分期及临床表现无显著关联。
结论 TyG指数可反映烟雾病患者胰岛素抵抗相关的糖脂代谢紊乱状态，未来或可用于评估烟雾病的个体代谢特征，为疾病的个体化精准干预提供参考。

文章导读： 本文关注烟雾病患者中胰岛素抵抗相关的糖脂代谢紊乱状态特点，通过与健康对照者的比较发现，TyG指数在烟雾病患者中明显升高；通过分层分析发现，烟雾病患者与健康对照者中的TyG指数均随年龄增加呈上升趋势。

关键词: 烟雾病; 卒中; 甘油三酯-葡萄糖指数

Abstract: Objective To investigate the relationship between the triglyceride-glucose (TyG) index and moyamoya disease (MMD) as well as its clinical manifestations.
Methods Patients with MMD who were hospitalized in the Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, and healthy controls during the same period were retrospectively and consecutively enrolled between August 2022 and May 2024. Propensity score matching for sex and age was performed, and the matched MMD patients were assigned to the MMD group, while the healthy controls were assigned to the control group. Demographic data, laboratory test results, and imaging data were collected for the MMD patients, and the TyG index was calculated. Logistic regression analysis was performed to explore the relationship between the TyG index and Suzuki stages as well as clinical manifestations of MMD.
Results A total of 205 patients with MMD and 231 healthy controls were enrolled. After propensity score matching, 187 patients in the MMD group and 187 healthy controls were finally matched. The TyG index was higher in the MMD group compared to the control group [8.54 (8.12-8.95) vs. 8.05 (7.81-8.42), P<0.001]. There were no significant differences in the TyG index among different Suzuki stages and clinical manifestations within the MMD group. Correlation analysis showed that the TyG index was positively correlated with age in both the MMD group (r=0.31, P<0.001) and the control group (r=0.28, P<0.001). Moreover, within the same age range, the TyG index was higher in the MMD group than in the control group. Logistic regression analysis showed that elevated TyG index was not significantly associated with Suzuki stages or clinical manifestations.
Conclusions The TyG index can reflect the glucose and lipid metabolic disturbances associated with insulin resistance in patients with MMD. In the future, it may be used to assess individual metabolic characteristics of MMD, providing a reference for personalized precision interventions.

Key words: Moyamoya disease; Stroke; Triglyceride-glucose index

中图分类号:

孙旭东, 曾超凡, 陈颢元, 李昊, 张岩, 张谦. 甘油三酯-葡萄糖指数在烟雾病患者中的特征分析：1项病例对照研究[J]. 中国卒中杂志, 2025, 20(10): 1270-1276.

SUN Xudong, ZENG Chaofan, CHEN Haoyuan, LI Hao, ZHANG Yan, ZHANG Qian. Analysis of Triglyceride-Glucose Index Characteristics in Patients with Moyamoya Disease: A Case-Control Study[J]. Chinese Journal of Stroke, 2025, 20(10): 1270-1276.

参考文献

[1] IHARA M，YAMAMOTO Y，HATTORI Y，et al. Moyamoya disease：diagnosis and interventions[J]. Lancet Neurol，2022，21（8）：747-758.
[2] SARKAR P，THIRUMURUGAN K. New insights into TNFα/PTP1B and PPARγ pathway through RNF213—a link between inflammation，obesity，insulin resistance，and moyamoya disease[J/OL]. Gene，2021，771：145340[2025-08-08]. https://doi.org/10.1016/j.gene.2020.145340.
[3] KERNAN W N，INZUCCHI S E，VISCOLI C M，et al. Impaired insulin sensitivity among nondiabetic patients with a recent TIA or ischemic stroke[J]. Neurology，2003，60（9）：1447-1451.
[4] AGO T，MATSUO R，HATA J，et al. Insulin resistance and clinical outcomes after acute ischemic stroke[J/OL]. Neurology，2018，90（17）：e1470-e1477[2025-08-08]. https://doi.org/10.1212/WNL.0000000000005358.
[5] YANG Y，HUANG X T，WANG Y G，et al. The impact of triglyceride-glucose index on ischemic stroke：a systematic review and meta-analysis[J/OL]. Cardiovasc Diabetol，2023，22：2[2025-08-08]. https://doi.org/10.1186/s12933-022-01732-0.
[6] UNGER G，BENOZZI S F，PERRUZZA F，et al. Triglycerides and glucose index：a useful indicator of insulin resistance[J]. Endocrinol Nutr，2014，61（10）：533-540.
[7] TAO L C，XU J N，WANG T T，et al. Triglyceride-glucose index as a marker in cardiovascular diseases：landscape and limitations[J/OL]. Cardiovasc Diabetol，2022，21：68[2025-08-08]. https://doi.org/10.1186/s12933-022-01511-x.
[8] FUJIMURA M，TOMINAGA T，KURODA S，et al. 2021 Japanese guidelines for the management of moyamoya disease：guidelines from the Research Committee on Moyamoya Disease and Japan Stroke Society[J]. Neurol Med Chir（Tokyo），2022，62（4）：165-170.
[9] SIMENTAL-MENDÍA L E，RODRÍGUEZ-MORÁN M，GUERRERO-ROMERO F. The product of fasting glucose and triglycerides as surrogate for identifying insulin resistance in apparently healthy subjects[J]. Metab Syndr Relat Disord，2008，6（4）：299-304.
[10] WU Y L，YANG Y B，ZHANG J S，et al. The change of triglyceride-glucose index may predict incidence of stroke in the general population over 45 years old[J/OL]. Cardiovasc Diabetol，2023，22：132[2025-08-08]. https://doi.org/10.1186/s12933-023-01870-z.
[11] MOLINA M N，FERDER L，MANUCHA W. Emerging role of nitric oxide and heat shock proteins in insulin resistance[J/OL]. Curr Hypertens Rep，2016，18：1[2025-08-08]. https://doi.org/10.1007/s11906-015-0615-4.
[12] HE S H，WANG Y R，LIU Z Q，et al. Metabolomic signatures associated with pathological angiogenesis in moyamoya disease[J/OL]. Clin Transl Med，2023，13（12）：e1492[2025-08-08]. https://doi.org/10.1002/ctm2.1492.
[13] NISHIKAWA T，KUKIDOME D，SONODA K，et al. Impact of mitochondrial ROS production in the pathogenesis of insulin resistance[J/OL]. Diabetes Res Clin Pract，2007，77 Suppl 1：S161-S164[2025-08-08]. https://doi.org/10.1016/j.diabres.2007.01.071.
[14] CHEN A Q，FANG Z，CHEN X L，et al. Microglia-derived TNF-α mediates endothelial necroptosis aggravating blood brain-barrier disruption after ischemic stroke[J/OL]. Cell Death Dis，2019，10（7）：487[2025-08-08]. https://doi.org/10.1038/s41419-019-1716-9.
[15] LIU W，SUN J，SHI Z Y，et al. Circulating inflammatory cytokine associated with poor prognosis in moyamoya disease：a prospective cohort study[J/OL]. J Clin Med，2023，12（3）：823[2025-08-08]. https://doi.org/10.3390/jcm12030823.
[16] EL HAOUARI M，ROSADO J A. Platelet signalling abnormalities in patients with type 2 diabetes mellitus：a review[J]. Blood Cells Mol Dis，2008，41（1）：119-123.
[17] GERRITS A J，KOEKMAN C A，VAN HAEFTEN T W，et al. Platelet tissue factor synthesis in type 2 diabetic patients is resistant to inhibition by insulin[J]. Diabetes，2010，59（6）：1487-1495.

甘油三酯-葡萄糖指数在烟雾病患者中的特征分析：1项病例对照研究

Analysis of Triglyceride-Glucose Index Characteristics in Patients with Moyamoya Disease: A Case-Control Study

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

[1]	刘丽旭. 融合·闭环·精准：神经调控技术重塑卒中康复[J]. 中国卒中杂志, 2025, 20(9): 1073-1077.
[2]	夏小茜, 康晓宇, 贾凌云, 王倩惠, 张琳瑶, 张若晴, 王艺铮, 吴晓莉, 陈小刚, 刘丽旭. 基于MI-SSVEP的脑机接口辅助康复训练对卒中患者上肢运动功能的影响[J]. 中国卒中杂志, 2025, 20(9): 1087-1096.
[3]	栾伟, 魏达, 马超, 张华伟, 李铁民, 彭玉涛, 刘长青. 侵入性迷走神经电刺激联合康复训练治疗缺血性卒中后上肢运动功能障碍的可行性、疗效与安全性研究[J]. 中国卒中杂志, 2025, 20(9): 1097-1103.
[4]	解正绮, 宋晓微. ICAS所致急性缺血性卒中的斑块特征与发病机制关系研究[J]. 中国卒中杂志, 2025, 20(9): 1104-1112.
[5]	柴昌, 胡全忠. 红细胞压积与海拔梯度对中高海拔地区轻型缺血性卒中患者卒中后睡眠障碍的影响研究[J]. 中国卒中杂志, 2025, 20(9): 1113-1120.
[6]	苗连海, 陈继群, 宋诗涛, 杨志勇, 赵辉. 基于GDS-15评价老年卒中后抑郁状态的影响因素及其纵向分析[J]. 中国卒中杂志, 2025, 20(9): 1131-1136.
[7]	赵殿兰, 王燕, 张宏君, 董梦甜, 胡涛. 基于吞咽造影时间学及运动学参数构建卒中后吞咽障碍短期转归不良的列线图预测模型[J]. 中国卒中杂志, 2025, 20(9): 1146-1156.
[8]	黄媛媛, 周婉冰, 李小燕, 卢政红, 洪小丹. β-羟基丁酸通过TRIB3/Akt/mTOR通路调控蛋白质合成和降解平衡改善卒中相关性肌少症[J]. 中国卒中杂志, 2025, 20(9): 1167-1178.
[9]	侯志凯, 何子骏, 于洮, 沈晨阳, 王嵘, 马宁. 经颈动脉血运重建术治疗颈动脉狭窄1例并文献分析[J]. 中国卒中杂志, 2025, 20(9): 1179-1185.
[10]	濮月华, 董培, 荆京, 董可辉, 李子孝, 龚浠平. 当急性缺血性卒中遇上“栓子雨”[J]. 中国卒中杂志, 2025, 20(9): 1193-1197.
[11]	李欢, 于向明. 急性缺血性卒中DWI-FLAIR不匹配影像学判读研究进展[J]. 中国卒中杂志, 2025, 20(9): 1198-1202.
[12]	马锐华, 熊俞婷, 王春娟. 基于智能手机的卒中后院外智慧管理系统应用需求的质性研究[J]. 中国卒中杂志, 2025, 20(8): 943-949.
[13]	熊俞婷, 王春娟. 人工智能在神经系统疾病中的应用进展[J]. 中国卒中杂志, 2025, 20(8): 950-957.
[14]	于骁, 孙亚召, 黄捷. C反应蛋白-甘油三酯-葡萄糖指数与进展性卒中的相关性研究[J]. 中国卒中杂志, 2025, 20(8): 977-984.
[15]	卢肖, 张玉梅, 陈心雅. 卒中后感觉性失语症患者语言功能与非语言认知功能的相关性[J]. 中国卒中杂志, 2025, 20(8): 985-991.