关键词: 急性脑梗死; 梗死部位; 白质病变; 认知障碍

Abstract:

【Abstract】 Objective To analyze the influences of infarction locations and white matter lesions on vascular cognitive impairment (VCI) of acute cerebral infarction patients at their early stages. Methods Consecutive acute cerebral infarction patients underwent Clinical Dementia Rating (CDR), Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA). Analyses were performed to study the association between cognitive impairment and infarction locations including cortical infarction, subcortical critical site infarction, subcortical non-critical site infarction and white matter lesions including leukoaraiosis and non-leukoaraiosis. Results The mean age of cognitive impaired patients was significantly higher than that of normal cognition patients (67.31 10.88 vs 57.09 9.91, P=0.015). The mean score of National Institute of Health Stroke Scale (NIHSS) of cognitive impaired patients was significantly higher than that of normal cognition patients (3.0[2.0~4.0] vs 1.0[1.0~2.0], P=0.012). The mean score of Barthel index of cognitive impaired patients was significantly lower than that of normal cognition patients (81.67 23.55 vs 95.91 12.00, P=0.029). There was significant difference in infarction locations between two groups of patients (P=0.042). Cortical infarction was more popular in vascular cognitive impaired patients. The mean score of the domain of visuospatial executive function in the cortical stroke patients was significantly lower than that of subcortical non-coritical site stroke ones (1.5[0.0~3.0] vs 3.0[2.0~4.0], P=0.016). White matter lesions have no significant relationship with VCI. Conclusion Age, severe neurological deficits, cortical infarcton and ability of daily life were highly related with cognitive impairment of the acute cerebral infarction patients.

Key words: Acute cerebral infarction; Infarction location; White matter lesion; Cognitive impairment